Literature DB >> 2531292

The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs.

N Sagata1, N Watanabe, G F Vande Woude, Y Ikawa.   

Abstract

The c-mos proto-oncogene product, pp39mos, is present in unfertilized Xenopus eggs, and disappears on fertilization. Microinjection of synthetic mos RNA into two-cell embryos induces cleavage arrest at metaphase. By contrast, egg cytosol extracts, when immunodepleted of endogenous pp39mos, lose their cleavage-arresting activity in injected embryos. These results demonstrate that Mos protein is the cytostatic factor CSF, long known as an endogenous meiotic inhibitor in vertebrate eggs.

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Year:  1989        PMID： 2531292     DOI： 10.1038/342512a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  146 in total

1.  Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation In vivo.

Authors:  M L Sohaskey; J E Ferrell
Journal:  Mol Biol Cell       Date:  1999-11       Impact factor: 4.138

2.  p53 functions as a cell cycle control protein in osteosarcomas.

Authors:  L Diller; J Kassel; C E Nelson; M A Gryka; G Litwak; M Gebhardt; B Bressac; M Ozturk; S J Baker; B Vogelstein
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

3.  pp39mos is associated with p34cdc2 kinase in c-mosxe-transformed NIH 3T3 cells.

Authors:  R Zhou; I Daar; D K Ferris; G White; R S Paules; G Vande Woude
Journal:  Mol Cell Biol       Date:  1992-08       Impact factor: 4.272

4.  Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest.

Authors:  Keita Ohsumi; Ayako Koyanagi; Tomomi M Yamamoto; Tetsuya Gotoh; Takeo Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-16       Impact factor: 11.205

5.  Identification of a negative regulatory element that inhibits c-mos transcription in somatic cells.

Authors:  S S Zinkel; S K Pal; J Szeberényi; G M Cooper
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

6.  H-ras(val12) induces cytoplasmic but not nuclear events of the cell cycle in small Xenopus oocytes.

Authors:  A D Johnson; R J Cork; M A Williams; K R Robinson; L D Smith
Journal:  Cell Regul       Date:  1990-06

7.  Mouse Emi2 as a distinctive regulatory hub in second meiotic metaphase.

Authors:  Toru Suzuki; Emi Suzuki; Naoko Yoshida; Atsuko Kubo; Hongmei Li; Erina Okuda; Manami Amanai; Anthony C F Perry
Journal:  Development       Date:  2010-08-19       Impact factor: 6.868

8.  The Mos/mitogen-activated protein kinase (MAPK) pathway regulates the size and degradation of the first polar body in maturing mouse oocytes.

Authors:  T Choi; K Fukasawa; R Zhou; L Tessarollo; K Borror; J Resau; G F Vande Woude
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

9.  Emi2 Is Essential for Mouse Spermatogenesis.

Authors:  Lakshmi Gopinathan; Radoslaw Szmyd; Diana Low; M Kasim Diril; Heng-Yu Chang; Vincenzo Coppola; Kui Liu; Lino Tessarollo; Ernesto Guccione; Ans M M van Pelt; Philipp Kaldis
Journal:  Cell Rep       Date:  2017-07-18       Impact factor: 9.423

10.  A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.

Authors:  Jeffrey J Tung; David V Hansen; Kenneth H Ban; Alexander V Loktev; Matthew K Summers; John R Adler; Peter K Jackson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-07       Impact factor: 11.205
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