Marc Miravitlles1, Jesús Molina2, José Antonio Quintano3, Anna Campuzano4, Joselín Pérez4, Carlos Roncero5. 1. Department of Pneumology, Hospital Universitari Vall d'Hebron, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. Electronic address: mmiravitlles@vhebron.net. 2. Centro de Salud Francia, Dirección Asistencial Oeste, Madrid, Spain. 3. Centro de Salud Lucena I, Lucena, Córdoba, Spain. 4. Medical Department Grupo Ferrer, Barcelona, Spain. 5. Outpatient Drug Clinic (CAS) Vall d'Hebron, Psychiatry Department, Vall d'Hebron Hospital-ASPB, Ciber de Salud Mental (CIBERSAM), Barcelona, Spain; Department of Psychiatry and Legal Medicine, Universitat Autónoma de Barcelona, Spain.
Abstract
BACKGROUND: Depression is very prevalent in COPD and may be associated with poor clinical outcomes. METHOD: This was a multicenter, cross-sectional study aimed at evaluating the prevalence of depression and moderate to severe depression in COPD. Depressive symptoms were evaluated with the Beck's Depression Inventory. The COPD assessment test (CAT) and the EuroQoL-5 dimensions (EQ-5D) questionnaires were used to evaluate health-related quality of life (HRQoL). Severity of COPD was assessed with the BODEx index and physical activity was estimated by the mean self-declared time walked per day. RESULTS: A total of 836 patients were included and up to 74.6% had some degree of depression with 51.5% having moderate to severe depression. On multivariate analysis, moderate to severe depression was associated with suicidal ideation (OR, 6.12; 95% confidence interval (CI), 1.36-28.24), worse quality of life: EQ-5D (OR, 0.89; 95%CI, 0.86-0.93) and worse CAT scores (OR, 1.32; 95%CI, 1.19-1.46). When questionnaires were not included in the analysis, significant depression was associated with the Charlson comorbidity index, minutes walked per day and BODEx score. CONCLUSIONS: Depression is frequent in COPD and is associated with suicidal ideation, impaired HRQoL, increase in comorbidities, a reduction in physical activity and increased severity of COPD measured by the BODEx index.
BACKGROUND:Depression is very prevalent in COPD and may be associated with poor clinical outcomes. METHOD: This was a multicenter, cross-sectional study aimed at evaluating the prevalence of depression and moderate to severe depression in COPD. Depressive symptoms were evaluated with the Beck's Depression Inventory. The COPD assessment test (CAT) and the EuroQoL-5 dimensions (EQ-5D) questionnaires were used to evaluate health-related quality of life (HRQoL). Severity of COPD was assessed with the BODEx index and physical activity was estimated by the mean self-declared time walked per day. RESULTS: A total of 836 patients were included and up to 74.6% had some degree of depression with 51.5% having moderate to severe depression. On multivariate analysis, moderate to severe depression was associated with suicidal ideation (OR, 6.12; 95% confidence interval (CI), 1.36-28.24), worse quality of life: EQ-5D (OR, 0.89; 95%CI, 0.86-0.93) and worse CAT scores (OR, 1.32; 95%CI, 1.19-1.46). When questionnaires were not included in the analysis, significant depression was associated with the Charlson comorbidity index, minutes walked per day and BODEx score. CONCLUSIONS:Depression is frequent in COPD and is associated with suicidal ideation, impaired HRQoL, increase in comorbidities, a reduction in physical activity and increased severity of COPD measured by the BODEx index.
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Authors: Hoi Nam Tse; Cee Zhung Steven Tseng; King Ying Wong; Lai Yun Ng; Tin Lok Lai; Kwok Sang Yee Journal: Lung Date: 2016-05-02 Impact factor: 2.584
Authors: Cristina Esquinas; Maria A Ramon; Alexa Nuñez; Jesús Molina; José A Quintano; Miguel Roman-Rodríguez; Karlos Naberan; Carl Llor; Carlos Roncero; Marc Miravitlles; Miriam Barrecheguren Journal: Qual Life Res Date: 2019-10-31 Impact factor: 4.147
Authors: Iván Dueñas-Espín; Heleen Demeyer; Elena Gimeno-Santos; Michael I Polkey; Nicholas S Hopkinson; Roberto A Rabinovich; Fabienne Dobbels; Niklas Karlsson; Thierry Troosters; Judith Garcia-Aymerich Journal: Int J Chron Obstruct Pulmon Dis Date: 2016-06-10
Authors: Maria A Ramon; Cristina Esquinas; Miriam Barrecheguren; Eulogio Pleguezuelos; Jesús Molina; José A Quintano; Miguel Roman-Rodríguez; Karlos Naberan; Carl Llor; Carlos Roncero; Marc Miravitlles Journal: Int J Chron Obstruct Pulmon Dis Date: 2017-04-13
Authors: Carlos Roncero; Ana Isabel Campuzano; Jose Antonio Quintano; Jesús Molina; Joselín Pérez; Marc Miravitlles Journal: Int J Chron Obstruct Pulmon Dis Date: 2016-03-16
Authors: Marc Miravitlles; Claus Vogelmeier; Nicolas Roche; David Halpin; João Cardoso; Alexander G Chuchalin; Hannu Kankaanranta; Thomas Sandström; Paweł Śliwiński; Jaromir Zatloukal; Francesco Blasi Journal: Eur Respir J Date: 2016-01-21 Impact factor: 16.671