Foni Bushon Biswas1, Tapashi Ghosh Roy2, Md Atiar Rahman3, Talha Bin Emran4. 1. Department of Chemistry, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh. 2. Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh. 3. Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-4331, Bangladesh. Electronic address: atiarh@yahoo.com. 4. BGC Trust University Bangladesh, Chittagong, Bangladesh.
Abstract
OBJECTIVE: To evaluate the antibacterial and antifungal effects of cadmium(II) complexes with hexamethyltetraazacyclotetradecadiene ligands. METHODS: Five coordinated square pyramidal cadmium(II) complexes and six coordinated square octahedral cadmium(II) complexes have been synthesized by interaction of 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene (denoted by L.2HClO4) and C-chiral isomers of its saturated analogue (denoted by 'teta' and 'tetb') with different salts of Cd(2+) ion [e.g. CdI2, Cd(NO3)2·6H2O, CdCl2·2H2O and Cd(ClO4)2·6H2O] in methanolic solution. Complexes of the ligands were investigated for antibacterial activity by disc diffusion method and antifungal effect by poisoned food technique. RESULTS: The newly synthesized cadmium(II) complexes of the ligands were screened as potential antimicrobial agent against a number of medically important bacteria (Staphylococcus aureus, Bacillus cereus, Salmonella typhi, Shigella dysenteriae and Escherichia coli) and against two fungi (Candida albicans and Aspergillus aculeatus). The growth inhibiting activity of the ligands and complexes against bacteria and fungi were compared with the standard antibiotic ampicillin and commercially important antifungal agent, griseofulvin respectively. Among them some of the macrocyclic complexes were found to be more fungitoxic and antibacterial than the reference antifungal drug griseofulvin and antibacterial drug ampicillin respectively. CONCLUSIONS: Hexamethyltetraazacyclotetradecadiene ligands and its complexes could be considered as very potential antibacterial and antifungal agent with further investigation.
OBJECTIVE: To evaluate the antibacterial and antifungal effects of cadmium(II) complexes with hexamethyltetraazacyclotetradecadiene ligands. METHODS: Five coordinated square pyramidal cadmium(II) complexes and six coordinated square octahedral cadmium(II) complexes have been synthesized by interaction of 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene (denoted by L.2HClO4) and C-chiral isomers of its saturated analogue (denoted by 'teta' and 'tetb') with different salts of Cd(2+) ion [e.g. CdI2, Cd(NO3)2·6H2O, CdCl2·2H2O and Cd(ClO4)2·6H2O] in methanolic solution. Complexes of the ligands were investigated for antibacterial activity by disc diffusion method and antifungal effect by poisoned food technique. RESULTS: The newly synthesized cadmium(II) complexes of the ligands were screened as potential antimicrobial agent against a number of medically important bacteria (Staphylococcus aureus, Bacillus cereus, Salmonella typhi, Shigella dysenteriae and Escherichia coli) and against two fungi (Candida albicans and Aspergillus aculeatus). The growth inhibiting activity of the ligands and complexes against bacteria and fungi were compared with the standard antibiotic ampicillin and commercially important antifungal agent, griseofulvin respectively. Among them some of the macrocyclic complexes were found to be more fungitoxic and antibacterial than the reference antifungal drug griseofulvin and antibacterial drug ampicillin respectively. CONCLUSIONS:Hexamethyltetraazacyclotetradecadiene ligands and its complexes could be considered as very potential antibacterial and antifungal agent with further investigation.
Authors: Md Masudur Rahman; Md Josim Uddin; A S M Ali Reza; Abu Montakim Tareq; Talha Bin Emran; Jesus Simal-Gandara Journal: Plants (Basel) Date: 2021-04-08