Literature DB >> 25311814

Regulation of lncRNA expression.

Zhuomin Wu1, Xiaoxia Liu, Li Liu, Houliang Deng, Jingjing Zhang, Qian Xu, Bohong Cen, Aimin Ji.   

Abstract

Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.

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Year:  2014        PMID： 25311814      PMCID： PMC6275606          DOI： 10.2478/s11658-014-0212-6

Source DB:  PubMed          Journal:  Cell Mol Biol Lett        ISSN： 1425-8153            Impact factor:   5.787


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