Literature DB >> 25309004

An efficient synthesis of 3-(N-piperidinemethyl)-2, 2, 5, 5-tetramethyl-1-oxy-3-pyrroline, a promising radioprotector for cancer radiotherapy.

Haitao Wu1, Vincent Coble1, Olga Vasalatiy1, Rolf E Swenson1, Murali C Krishna2, James B Mitchell2.   

Abstract

Nitroxides can ameliorate the toxic effects of radiation during cancer therapy. Nitroxides are paramagnetic and can be used in magnetic resonance imaging (MRI) and electron paramagnetic resonance imaging (EPRI) to monitor in vivo oxidative stress status. Compound 5 (3-(N-piperidinemethyl)-2, 2, 5, 5-tetramethyl-1-oxy-3-pyrroline) was found to be the most effective nitroxide radioprotector. An efficient synthesis for this promising radioprotector was developed.

Entities:  

Keywords:  EPRI; MRI; Nitroxide; radioprotector; redox

Year:  2014        PMID： 25309004      PMCID： PMC4190098          DOI： 10.1016/j.tetlet.2014.08.028

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  10 in total

Review 1.  Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer.

Authors:  Tara O Henderson; Alison Amsterdam; Smita Bhatia; Melissa M Hudson; Anna T Meadows; Joseph P Neglia; Lisa R Diller; Louis S Constine; Robert A Smith; Martin C Mahoney; Elizabeth A Morris; Leslie L Montgomery; Wendy Landier; Stephanie M Smith; Leslie L Robison; Kevin C Oeffinger
Journal:  Ann Intern Med       Date:  2010-04-06       Impact factor: 25.391

2.  A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.

Authors:  Ryan M Davis; Anastasia L Sowers; William DeGraff; Marcelino Bernardo; Angela Thetford; Murali C Krishna; James B Mitchell
Journal:  Free Radic Biol Med       Date:  2011-05-25       Impact factor: 7.376

3.  Tempol, a stable free radical, is a novel murine radiation protector.

Authors:  S M Hahn; Z Tochner; C M Krishna; J Glass; L Wilson; A Samuni; M Sprague; D Venzon; E Glatstein; J B Mitchell
Journal:  Cancer Res       Date:  1992-04-01       Impact factor: 12.701

4.  Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model.

Authors:  Ana P Cotrim; Anastasia L Sowers; Beatrijs M Lodde; Joseph M Vitolo; Albert Kingman; Angelo Russo; James B Mitchell; Bruce J Baum
Journal:  Clin Cancer Res       Date:  2005-10-15       Impact factor: 12.531

Review 5.  Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation.

Authors:  Andrea L DiCarlo; Carmen Maher; John L Hick; Dan Hanfling; Nicholas Dainiak; Nelson Chao; Judith L Bader; C Norman Coleman; David M Weinstock
Journal:  Disaster Med Public Health Prep       Date:  2011-03       Impact factor: 1.385

Review 6.  Nitroxides as cancer imaging agents.

Authors:  Ryan M Davis; James B Mitchell; Murali C Krishna
Journal:  Anticancer Agents Med Chem       Date:  2011-05-01       Impact factor: 2.505

7.  Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage.

Authors:  M C Krishna; W DeGraff; O H Hankovszky; C P Sár; T Kálai; J Jeko; A Russo; J B Mitchell; K Hideg
Journal:  J Med Chem       Date:  1998-08-27       Impact factor: 7.446

8.  Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol.

Authors:  J B Mitchell; W DeGraff; D Kaufman; M C Krishna; A Samuni; E Finkelstein; M S Ahn; S M Hahn; J Gamson; A Russo
Journal:  Arch Biochem Biophys       Date:  1991-08-15       Impact factor: 4.013

9.  Evaluation of tempol radioprotection in a murine tumor model.

Authors:  S M Hahn; F J Sullivan; A M DeLuca; C M Krishna; N Wersto; D Venzon; A Russo; J B Mitchell
Journal:  Free Radic Biol Med       Date:  1997       Impact factor: 7.376

10.  Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging.

Authors:  Ana P Cotrim; Fuminori Hyodo; Ken-Ichiro Matsumoto; Anastasia L Sowers; John A Cook; Bruce J Baum; Murali C Krishna; James B Mitchell
Journal:  Clin Cancer Res       Date:  2007-08-15       Impact factor: 12.531
  10 in total
  1 in total

1.  A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta.

Authors:  Silvia Hilt; Robin Altman; Tamás Kálai; Izumi Maezawa; Qizhi Gong; Sebastian Wachsmann-Hogiu; Lee-Way Jin; John C Voss
Journal:  Molecules       Date:  2018-08-12       Impact factor: 4.411
  1 in total

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