Literature DB >> 25308845

Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment.

R J Bułdak1, M Skonieczna, Ł Bułdak, N Matysiak, Ł Mielańczyk, G Wyrobiec, M Kukla, M Michalski, K Żwirska-Korczala.   

Abstract

The aim of the study was to assess the expression and subcellular localization of visfatin in HCT-116 colorectal carcinoma cells after cytokinesis failure using Cytochalasin B (CytB) and the mechanism of apoptosis of cells after CytB. We observed translocation of visfatin's antigen in cytB treated colorectal carcinoma HCT-116 cells from cytosol to nucleus. Statistical and morphometric analysis revealed significantly higher area-related numerical density visfatin-bound nano-golds in the nuclei of cytB-treated HCT-116 cells compared to cytosol. Reverse relation to visfatin subcellular localization was observed in un-treated HCT-116 cells. The total amount of visfatin protein and visfatin mRNA level in HCT-116 cells was also decreased after CytB treatment. Additionally, CytB significantly decreased cell survival, increased levels of G2/M fractions, induced bi-nuclei formation as well as increased reactive oxygen species (ROS) level in HCT-116 cells. CytB treatment showed cytotoxic effect that stem from oxidative stress and is connected with the changes in the cytoplasmic/nuclear amount of visfatin in HCT-116 cells.

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Year:  2014        PMID： 25308845      PMCID： PMC4194393          DOI： 10.4081/ejh.2014.2408

Source DB:  PubMed          Journal:  Eur J Histochem        ISSN： 1121-760X            Impact factor:   3.188


  33 in total

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2.  Short-term exposure to 50 Hz ELF-EMF alters the cisplatin-induced oxidative response in AT478 murine squamous cell carcinoma cells.

Authors:  Rafał Jakub Bułdak; Renata Polaniak; Lukasz Bułdak; Krystyna Zwirska-Korczala; Magdalena Skonieczna; Aleksandra Monsiol; Michał Kukla; Anna Duława-Bułdak; Ewa Birkner
Journal:  Bioelectromagnetics       Date:  2012-04-25       Impact factor: 2.010

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Journal:  Maturitas       Date:  2012-01-20       Impact factor: 4.342

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Journal:  Biochem Biophys Res Commun       Date:  2012-03-10       Impact factor: 3.575

5.  Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1).

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6.  Elevated serum visfatin/nicotinamide phosphoribosyl-transferase levels are associated with risk of postmenopausal breast cancer independently from adiponectin, leptin, and anthropometric and metabolic parameters.

Authors:  Maria Dalamaga; Konstantinos Karmaniolas; Evangelia Papadavid; Nicolaos Pelekanos; George Sotiropoulos; Antigoni Lekka
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Authors:  Snehal T Patel; Tina Mistry; James E P Brown; Janet E Digby; Raghu Adya; Ken M Desai; Harpal S Randeva
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Review 10.  [Obesity and cancer].

Authors:  J-L Schlienger; F Luca; S Vinzio; A Pradignac
Journal:  Rev Med Interne       Date:  2009-06-12       Impact factor: 0.728
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  4 in total

1.  Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth.

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Journal:  J Biol Chem       Date:  2019-04-11       Impact factor: 5.157

2.  Impact of Histochemistry on biomedical research: looking through the articles published in a long-established histochemical journal.

Authors:  C Pellicciari
Journal:  Eur J Histochem       Date:  2014-12-30       Impact factor: 3.188

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Authors:  Carlo Pellicciari
Journal:  Eur J Histochem       Date:  2016-12-16       Impact factor: 3.188

Review 4.  Histochemistry in biology and medicine: a message from the citing journals.

Authors:  Carlo Pellicciari
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  4 in total

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