Michele Fornaro1, Domenico De Berardis2, Concetta De Pasquale3, Luisa Indelicato4, Rocco Pollice5, Alessandro Valchera6, Giampaolo Perna7, Felice Iasevoli8, Carmine Tomasetti9, Giovanni Martinotti10, Ann Sarah Koshy11, Ole Bernt Fasmer12, Ketil Joachim Oedegaard13. 1. Department of Education Science, University of Catania, Catania, Italy. Electronic address: dott.fornaro@gmail.com. 2. National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4, Teramo, Italy. Electronic address: dodebera@aliceposta.it. 3. Department of Education Science, University of Catania, Catania, Italy. Electronic address: depasqua@unict.it. 4. Department of Education Science, University of Catania, Catania, Italy. Electronic address: luisa.indelicato@hotmail.it. 5. Service for Monitoring and early Intervention against psychoLogical and mEntal suffering in young people" (SMILE), L'Aquila University, Italy. Electronic address: rocco.pollice@cc.univaq.it. 6. Hermanas Hospitalarias, Villa San Giuseppe Hospital, 63100 Ascoli Piceno, Italy. Electronic address: a.valchera@ospedaliere.it. 7. Department of Clinical Neuroscience, Villa San Benedetto Menni, Hermanas Hospitalarias, Albese con Cassano, Como, Italy. Electronic address: pernagp@gmail.com. 8. Department of Neuroscience, Reproductive Sciences and Odontostomatology, University "Federico II" of Naples, Via Pansini 5, 80131 Naples, Italy. Electronic address: felix_ias@hotmail.com. 9. Department of Neuroscience, Reproductive Sciences and Odontostomatology, University "Federico II" of Naples, Via Pansini 5, 80131 Naples, Italy. Electronic address: carmine.tomasetti@gmail.com. 10. Department of Neurosciences and Imaging, University "G. d'Annunzio" of Chieti, 66013 Chieti, Italy. Electronic address: giovanni.martinotti@gmail.com. 11. St. John's National Academy of Health Sciences, Bangalore, India. Electronic address: ann007sarah@gmail.com. 12. Department of Clinical Medicine, Section for Psychiatry, University of Bergen, Bergen, Norway. Electronic address: ole.fasmer@kliniskmedisin.uib.no. 13. Department of Psychiatry, University of Bergen, Bergen, Norway. Electronic address: ketil.odegaard@helse-bergen.no.
Abstract
BACKGROUND: The prevalence and clinical features associated with bipolar disorders (BDs)-migraine comorbidity have been reported inconsistently across different studies, therefore warranting a systematic review on the matter. METHODS: A systematic review was conducted in accordance with the PRISMA statement searching major electronic databases for documents indexed between January, 2000 and July, 2014. Eligible studies were those including quantitative data on prevalence rates and clinical features associated to BD-migraine comorbidity; case reports excluded. Three authors independently conducted searches, quality assessment of the studies and data extraction. RESULTS: Several cross-sectional studies, and a handful of retrospective follow-up studies or non-systematic reviews assessed the prevalence and/or the clinical correlates of migraine-BD comorbidity. High prevalence rates and a significant burden of BD-migraine comorbidity were common findings, particularly in case of BD-II women (point-prevalence rates up to 77%), migraine with aura (up to 53%) and/or cyclothymic temperament (up to 45% of the cases). LIMITATIONS: Some of the biases encountered in a few studies accounted by the present review may nonetheless have hampered the generalizability of the overall conclusions drawn herein. CONCLUSIONS: BD-migraine comorbidity may comprise of a sub-phenotype of BDs requiring patient-tailored therapeutic interventions to achieve an optimal outcome. Specifically, additional studies including longitudinal follow-up studies are aimed in order to shed further light on the actual prevalence rates and clinical features associated to BD-migraine comorbidity, with a special emphasis towards the clinically suggestive potential connection between mixed features, bipolar depression, migraine, and increased risk for suicidality. PROSPERO registration number: CRD42014009335.
BACKGROUND: The prevalence and clinical features associated with bipolar disorders (BDs)-migraine comorbidity have been reported inconsistently across different studies, therefore warranting a systematic review on the matter. METHODS: A systematic review was conducted in accordance with the PRISMA statement searching major electronic databases for documents indexed between January, 2000 and July, 2014. Eligible studies were those including quantitative data on prevalence rates and clinical features associated to BD-migraine comorbidity; case reports excluded. Three authors independently conducted searches, quality assessment of the studies and data extraction. RESULTS: Several cross-sectional studies, and a handful of retrospective follow-up studies or non-systematic reviews assessed the prevalence and/or the clinical correlates of migraine-BD comorbidity. High prevalence rates and a significant burden of BD-migraine comorbidity were common findings, particularly in case of BD-II women (point-prevalence rates up to 77%), migraine with aura (up to 53%) and/or cyclothymic temperament (up to 45% of the cases). LIMITATIONS: Some of the biases encountered in a few studies accounted by the present review may nonetheless have hampered the generalizability of the overall conclusions drawn herein. CONCLUSIONS:BD-migraine comorbidity may comprise of a sub-phenotype of BDs requiring patient-tailored therapeutic interventions to achieve an optimal outcome. Specifically, additional studies including longitudinal follow-up studies are aimed in order to shed further light on the actual prevalence rates and clinical features associated to BD-migraine comorbidity, with a special emphasis towards the clinically suggestive potential connection between mixed features, bipolar depression, migraine, and increased risk for suicidality. PROSPERO registration number: CRD42014009335.
Authors: Ole Kristian Drange; Arne Einar Vaaler; Gunnar Morken; Ole Andreas Andreassen; Ulrik Fredrik Malt; Per Ivar Finseth Journal: Int J Bipolar Disord Date: 2018-09-10
Authors: Nicole M Sekula; Anastasia K Yocum; Steven Anderau; Melvin G McInnis; David F Marshall Journal: Brain Behav Date: 2022-05-05 Impact factor: 3.405