Literature DB >> 25305755

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors.

Ming Zhang1, Yuxuan Wang1, Sian Jones2, Mark Sausen2, Kevin McMahon1, Rajni Sharma3, Qing Wang1, Allan J Belzberg4, Kaisorn Chaichana4, Gary L Gallia4, Ziya L Gokaslan4, Greg J Riggins4, Jean-Paul Wolinksy4, Laura D Wood3, Elizabeth A Montgomery3, Ralph H Hruban3, Kenneth W Kinzler1, Nickolas Papadopoulos1, Bert Vogelstein1, Chetan Bettegowda5.   

Abstract

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

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Year:  2014        PMID： 25305755      PMCID： PMC4383254          DOI： 10.1038/ng.3116

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  20 in total

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  109 in total

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Review 10.  The Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics.

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