Elisabetta Cotti1, Elia Schirru2, Elio Acquas3, Paolo Usai4. 1. Department of Conservative Dentistry and Endodontics, School of Dentistry, University of Cagliari, Italy. Electronic address: cottiend@tin.it. 2. Department of Conservative Dentistry and Endodontics, School of Dentistry, University of Cagliari, Italy; Department of Endodontology, Kings College Dental Institute, London, United Kingdom. 3. Department of Life and Environmental Sciences, School of Pharmacology, University of Cagliari, Italy. 4. Department of Gastroenterology, School of Medicine, University of Cagliari, Italy.
Abstract
INTRODUCTION: Apical periodontitis (AP) is the expression of a deficient balance between infection and the host immune response. METHODS: If reducing the bacterial load from the root canal and preventing its reinfection may lead to clinical success, then the integrity of the nonspecific immune system has a relevant influence on the outcome of endodontic treatment. RESULTS: Compromised immune systems and/or genetic alterations of the host's response may as well play an important role on the development, progression, and healing of AP. Thus, immunomodulatory drugs might have the potential to influence both the severity of AP and the outcome of endodontic treatment. Biologic medications are a new class of drugs of monoclonal antibodies or fusion proteins that include fragments of a peculiar cytokine receptor. Specific inflammatory molecules or cells, such as tumor necrosis factor, interleukins, and T or B cells, are the selective targets of these drugs. They modulate the altered immune response and perform an important role in the short-term treatment of chronic inflammatory diseases such as rheumatoid arthritis, refractory Crohn disease, or ulcerative colitis. Despite the clinical positive outcomes and their widespread use, the consequences of administering biologic medications on the development of the dental diseases have not been adequately investigated. CONCLUSIONS: The aim of this review was to give an overview of biologic medications, their composition, their mechanisms of action, and their possible implications on endodontic and other dental diseases.
INTRODUCTION:Apical periodontitis (AP) is the expression of a deficient balance between infection and the host immune response. METHODS: If reducing the bacterial load from the root canal and preventing its reinfection may lead to clinical success, then the integrity of the nonspecific immune system has a relevant influence on the outcome of endodontic treatment. RESULTS: Compromised immune systems and/or genetic alterations of the host's response may as well play an important role on the development, progression, and healing of AP. Thus, immunomodulatory drugs might have the potential to influence both the severity of AP and the outcome of endodontic treatment. Biologic medications are a new class of drugs of monoclonal antibodies or fusion proteins that include fragments of a peculiar cytokine receptor. Specific inflammatory molecules or cells, such as tumor necrosis factor, interleukins, and T or B cells, are the selective targets of these drugs. They modulate the altered immune response and perform an important role in the short-term treatment of chronic inflammatory diseases such as rheumatoid arthritis, refractory Crohn disease, or ulcerative colitis. Despite the clinical positive outcomes and their widespread use, the consequences of administering biologic medications on the development of the dental diseases have not been adequately investigated. CONCLUSIONS: The aim of this review was to give an overview of biologic medications, their composition, their mechanisms of action, and their possible implications on endodontic and other dental diseases.
Authors: Stella M F Lima; Mirna S Freire; Ana Paula C Cantuária; Danilo C M Martins; Ingrid A Amorim; Elaine M G L Dantas; Jade O Farias; Márcio B Castro; Jackson S Silva; Fernando A Barriviera; Maurício Barriviera; Jeeser A Almeida; Isadora A Uehara; Marcelo J B Silva; Ana Paula L Oliveira; Osmar N Silva; Robert E W Hancock; Octávio L Franco; Taia M B Rezende Journal: Clin Oral Investig Date: 2020-11-16 Impact factor: 3.573