Literature DB >> 25304381

TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma.

Jian-Peng Chen1, Jun Wang2, Yi Luan3, Cai-Xia Wang4, Wen-Huan Li4, Jin-Biao Zhang5, Dan Sha4, Rong Shen4, Yan-Gang Cui4, Zheng Zhang4, Li-Ming Zhang6, Wei-Bo Wang4.   

Abstract

Our study observed the relationship between transient receptor potential melastatin 7 (TRPM7) expression and the metastatic process of nasopharyngeal carcinoma (NPC). We found that TRPM7 was overexpressed in 102 out of 206 (49.5%) human NPC cases and was significantly associated with clinical stage and lymphatic and distant metastasis. The results suggested that TRPM7 promotes NPC cell migration and invasion in vitro. Further, TRPM7 was correlated with poor clinical outcome and was an independent predictor for 5-year overall survival rate (HR, 1.832; 95% CI, 1.237-4.146 [P = 0.041]). In conclusion, TRPM7 promotes the metastasis of NPC and may serve as a prognostic marker in NPC patients.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Metastasis; Migration; Nasopharyngeal carcinoma; Prognosis; TRPM7

Mesh：

Substances：

Year:  2014        PMID： 25304381     DOI： 10.1016/j.canlet.2014.09.032

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

Review 1.  Role of TRP ion channels in cancer and tumorigenesis.

Authors:  George Shapovalov; Abigael Ritaine; Roman Skryma; Natalia Prevarskaya
Journal:  Semin Immunopathol       Date:  2016-02-03       Impact factor: 9.623

2.  Pan-cancer analyses reveal the genetic and pharmacogenomic landscape of transient receptor potential channels.

Authors:  Tao Pan; Yueying Gao; Gang Xu; Ping Zhou; Si Li; Jing Guo; Haozhe Zou; Qi Xu; Xiaoyan Huang; Juan Xu; Yongsheng Li
Journal:  NPJ Genom Med       Date:  2022-05-25       Impact factor: 6.083

3.  Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis.

Authors:  Yi Qin; Zhi-Wei Liao; Jing-Yan Luo; Wen-Zhe Wu; An-Shang Lu; Pu-Xia Su; Bing-Quan Lai; Xiao-Xiao Wang
Journal:  Tumour Biol       Date:  2016-01-15

4.  TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation.

Authors:  Jeroen Middelbeek; Daan Visser; Linda Henneman; Alwin Kamermans; Arthur J Kuipers; Peter M Hoogerbrugge; Kees Jalink; Frank N van Leeuwen
Journal:  Oncotarget       Date:  2015-04-20

Review 5.  Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis).

Authors:  Julian Banerji
Journal:  Int J Mol Med       Date:  2015-07-15       Impact factor: 4.101

Review 6.  Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials.

Authors:  Fruzsina Kiss; Krisztina Pohóczky; Arpad Szállási; Zsuzsanna Helyes
Journal:  Int J Mol Sci       Date:  2020-09-02       Impact factor: 5.923

Review 7.  Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets.

Authors:  Chaochu Cui; Yongxi Zhang; Gang Liu; Shuhong Zhang; Jinghang Zhang; Xianwei Wang
Journal:  Explor Target Antitumor Ther       Date:  2021-06-28

8.  Development and validation of a TRP-related gene signature for overall survival prediction in lung adenocarcinoma.

Authors:  Min He; Gujie Wu; Ziheng Wang; Kuan Ren; Zheng Yang; Qun Xue
Journal:  Front Genet       Date:  2022-09-15       Impact factor: 4.772

9.  The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway.

Authors:  Pierre Rybarczyk; Alison Vanlaeys; Bertrand Brassart; Isabelle Dhennin-Duthille; Denis Chatelain; Henri Sevestre; Halima Ouadid-Ahidouch; Mathieu Gautier
Journal:  Neoplasia       Date:  2017-03-08       Impact factor: 5.715
  9 in total

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