Literature DB >> 2530392

Harnessing the therapeutic potential of atrial natriuretic peptide.

A G Jardine1, D B Northridge, J M Connell.   

Abstract

The biological actions of Atrial Natriuretic Peptide (ANP) make it potentially useful in the treatment of hypertension and heart failure. We review here the physiology of ANP, the effects of infusion in heart failure and hypertension and preliminary data suggesting that inhibition of endopeptidase 24.11, the enzyme degrading ANP, is an effective mechanism of raising circulating levels of endogenous ANP. Due to the rate of progress in this field we have restricted ourselves to recent work much of which is still available only in abstract form. For more complete accounts the reader is referred to recent reviews [9, 11, 14].

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Year:  1989        PMID： 2530392     DOI： 10.1007/bf01717347

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  30 in total

Review 1.  Central nervous system actions of atrial natriuretic factor.

Authors:  W K Samson
Journal:  Brain Res Bull       Date:  1988-06       Impact factor: 4.077

2.  Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.

Authors:  J L Sonnenberg; Y Sakane; A Y Jeng; J A Koehn; J A Ansell; L P Wennogle; R D Ghai
Journal:  Peptides       Date:  1988 Jan-Feb       Impact factor: 3.750

Review 3.  Role of endopeptidase-24.11 in the inactivation of atrial natriuretic peptide.

Authors:  A J Kenny; S L Stephenson
Journal:  FEBS Lett       Date:  1988-05-09       Impact factor: 4.124

4.  Low dose infusions of 26- and 28-amino acid human atrial natriuretic peptides in normal man.

Authors:  A M Richards; G Tonolo; P Montorsi; J Finlayson; R Fraser; G Inglis; A Towrie; J J Morton
Journal:  J Clin Endocrinol Metab       Date:  1988-03       Impact factor: 5.958

5.  Antihypertensive and hypotensive effects of atrial natriuretic factor in men.

Authors:  A B Weder; M A Sekkarie; M Takiyyuddin; N J Schork; S Julius
Journal:  Hypertension       Date:  1987-12       Impact factor: 10.190

Review 6.  Atrial natriuretic hormone, the renin-aldosterone axis, and blood pressure-electrolyte homeostasis.

Authors:  J H Laragh
Journal:  N Engl J Med       Date:  1985-11-21       Impact factor: 91.245

7.  Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers.

Authors:  A M Richards; M G Nicholls; H Ikram; M W Webster; T G Yandle; E A Espiner
Journal:  Lancet       Date:  1985-03-09       Impact factor: 79.321

8.  The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice.

Authors:  B P Roques; M C Fournié-Zaluski; E Soroca; J M Lecomte; B Malfroy; C Llorens; J C Schwartz
Journal:  Nature       Date:  1980-11-20       Impact factor: 49.962

9.  Specific inhibitors of endopeptidase 24.11 inhibit the metabolism of atrial natriuretic peptides in vitro and in vivo.

Authors:  G M Olins; P A Krieter; A J Trapani; K L Spear; P R Bovy
Journal:  Mol Cell Endocrinol       Date:  1989-02       Impact factor: 4.102

10.  Atrial natriuretic hormone has biological effects in man at physiological plasma concentrations.

Authors:  A M Richards; D McDonald; M A Fitzpatrick; M G Nicholls; E A Espiner; H Ikram; S Jans; S Grant; T Yandle
Journal:  J Clin Endocrinol Metab       Date:  1988-12       Impact factor: 5.958
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  1 in total

1.  Effects of atrial natriuretic factor on anterior pituitary hormone secretion in normal man.

Authors:  M Kentsch; R Lawrenz; P Ball; R Gerzer; G Müller-Esch
Journal:  Clin Investig       Date:  1992-07
  1 in total

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