Manit Srisurapanont1, Dianne Bautista2, Chia-Hui Chen3, Gang Wang4, Pichet Udomratn5, Kanokkwan Eurviriyanukul6. 1. Department of Psychiatry, Faculty of Medicine, Chiang Mai University, 110 Intavarorod Road, Si Poom, Muang, Chiang Mai 50200, Thailand. Electronic address: manit.s@cmu.ac.th. 2. Duke-NUS Graduate Medical School, Singapore; Singapore Clinical Research Institute, Singapore. 3. National Health Research Institute, Department of Psychiatry, Taipei Medical University Shuang-Ho Hospital, Taiwan. 4. Depression Center, Beijing Anding Hospital, Capital Medical University, Beijing, China. 5. Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. 6. Department of Psychiatry, Faculty of Medicine, Chiang Mai University, 110 Intavarorod Road, Si Poom, Muang, Chiang Mai 50200, Thailand.
Abstract
BACKGROUND: Subjective cognitive impairment (SCI) in major depressive disorder (MDD) is prevalent and correlated with disability. This study aimed to examine the prevalence rates and correlates of subjective memory deficit (SMD) and subjective concentration deficit (SCD) in medication-free, non-elderly Asians with MDD. METHODS: The SMD and SCD were assessed by using two items of the Symptom Checklist-90-Revised (SCL-90-R). Other measurements of interest included the Montgomery-Asberg Depression Rating Scale (MADRS), the Fatigue Severity Scale (FSS), the Sheehan Disability Scale (SDS), and the Short Form Health Survey (SF-36). Adjusted odds ratios with 95% confidence intervals were calculated. RESULTS: Of 515 participants from China, Korea, Malaysia, Singapore, Taiwan, and Thailand, 347 (67.4%) and 377 (73.2%) had SMD and SCD, respectively. In total, 420 participants (81.6%) had SMD alone, SCD alone, and both deficits. Severe depression and poor mental health were significant correlates of SMD. Severe depression, clinically significant disability, poor physical health, and poor mental health were significantly independent correlates of SCD. Compared with young adults (18-34 years), older adults aged 50-65 years had a significantly lower risk of SCD (OR=.33, 95% CI: .19-.57). LIMITATIONS: Only two SCL-90-R items were used to assess the SMD and SCD. The exclusion of MDD patients treated with psychotropic medications eliminated many patients commonly seen in typical clinic settings. CONCLUSION: SMD and SCD are prevalent in medication-free, non-elderly Asians with MDD. Both deficits are correlated with depression and mental health status. The independent correlation between SCD and disability underscores the crucial role of SCI in MDD.
BACKGROUND: Subjective cognitive impairment (SCI) in major depressive disorder (MDD) is prevalent and correlated with disability. This study aimed to examine the prevalence rates and correlates of subjective memory deficit (SMD) and subjective concentration deficit (SCD) in medication-free, non-elderly Asians with MDD. METHODS: The SMD and SCD were assessed by using two items of the Symptom Checklist-90-Revised (SCL-90-R). Other measurements of interest included the Montgomery-Asberg Depression Rating Scale (MADRS), the Fatigue Severity Scale (FSS), the Sheehan Disability Scale (SDS), and the Short Form Health Survey (SF-36). Adjusted odds ratios with 95% confidence intervals were calculated. RESULTS: Of 515 participants from China, Korea, Malaysia, Singapore, Taiwan, and Thailand, 347 (67.4%) and 377 (73.2%) had SMD and SCD, respectively. In total, 420 participants (81.6%) had SMD alone, SCD alone, and both deficits. Severe depression and poor mental health were significant correlates of SMD. Severe depression, clinically significant disability, poor physical health, and poor mental health were significantly independent correlates of SCD. Compared with young adults (18-34 years), older adults aged 50-65 years had a significantly lower risk of SCD (OR=.33, 95% CI: .19-.57). LIMITATIONS: Only two SCL-90-R items were used to assess the SMD and SCD. The exclusion of MDDpatients treated with psychotropic medications eliminated many patients commonly seen in typical clinic settings. CONCLUSION:SMD and SCD are prevalent in medication-free, non-elderly Asians with MDD. Both deficits are correlated with depression and mental health status. The independent correlation between SCD and disability underscores the crucial role of SCI in MDD.
Authors: Julie G Kosteniuk; Debra G Morgan; Megan E O'Connell; Andrew Kirk; Margaret Crossley; Norma J Stewart; Chandima P Karunanayake Journal: Dement Geriatr Cogn Dis Extra Date: 2016-05-03
Authors: Srisurapanont Manit; Mok Yee Ming; Yang Yen Kuang; Chan Herng-Nieng; Della Constantine D; Zainal Nor Zuraida; Jambunathan Stephen; Amir Nurmiati; Kalita Pranabi Journal: Clin Pract Epidemiol Ment Health Date: 2017-10-31