OBJECTIVE: The objective of this longitudinal study was to determine what typical vitamin D predictors influence the change in vitamin D status from mid-pregnancy to birth. METHODS:Plasma 25-hydroxyvitamin D [25(OH)D] was determined at mid-pregnancy (8-20 weeks gestation) and following birth (n = 193). Usual predictors of vitamin D status [body mass index (BMI), race, season] in addition to prenatal supplemental vitamin D intake and docosahexaenoic acid (DHA) status at delivery were assessed for their interaction on the change on plasma 25(OH)D concentration between the two time points. RESULTS:Forty-nine percent of women had inadequate vitamin D status [categorized as deficient (<30 nmol/L) or insufficient (30-49.9 nmol/L) by IOM guidelines] at mid-pregnancy and 82% were deficient or insufficient at birth. Plasma 25(OH)D concentration dropped 61% from mid-pregnancy to birth. Season of birth (F = 7.86, P = 0.006) and mid-pregnancy plasma 25(OH)D concentration (F = 6.17, P = 0.014) were significant variables in the change of vitamin D status while BMI, race, DHA status, and typical vitamin D intake (334 IU/day) from prenatal supplements did not have an effect. Women who delivered in summer and fall had a 1.5-fold greater plasma 25(OH)D concentration than women who delivered in winter in spring (41.1 ± 23.1 and 40.7 ± 20.5 nmol/L summer and fall, respectively, versus 27.7 ± 17.9 and 29.3 ± 21.4 nmol/L in winter and spring, respectively). CONCLUSIONS:Typical supplemental vitamin D intake during pregnancy did not prevent precipitous drops in maternal plasma 25(OH)D concentration. Clinicians and dietitians should be aware of the risk of inadequate vitamin D status in pregnant women in the United States relative to their initial vitamin D status and the season of birth.
RCT Entities:
OBJECTIVE: The objective of this longitudinal study was to determine what typical vitamin D predictors influence the change in vitamin D status from mid-pregnancy to birth. METHODS: Plasma 25-hydroxyvitamin D [25(OH)D] was determined at mid-pregnancy (8-20 weeks gestation) and following birth (n = 193). Usual predictors of vitamin D status [body mass index (BMI), race, season] in addition to prenatal supplemental vitamin D intake and docosahexaenoic acid (DHA) status at delivery were assessed for their interaction on the change on plasma 25(OH)D concentration between the two time points. RESULTS: Forty-nine percent of women had inadequate vitamin D status [categorized as deficient (<30 nmol/L) or insufficient (30-49.9 nmol/L) by IOM guidelines] at mid-pregnancy and 82% were deficient or insufficient at birth. Plasma 25(OH)D concentration dropped 61% from mid-pregnancy to birth. Season of birth (F = 7.86, P = 0.006) and mid-pregnancy plasma 25(OH)D concentration (F = 6.17, P = 0.014) were significant variables in the change of vitamin D status while BMI, race, DHA status, and typical vitamin D intake (334 IU/day) from prenatal supplements did not have an effect. Women who delivered in summer and fall had a 1.5-fold greater plasma 25(OH)D concentration than women who delivered in winter in spring (41.1 ± 23.1 and 40.7 ± 20.5 nmol/L summer and fall, respectively, versus 27.7 ± 17.9 and 29.3 ± 21.4 nmol/L in winter and spring, respectively). CONCLUSIONS: Typical supplemental vitamin D intake during pregnancy did not prevent precipitous drops in maternal plasma 25(OH)D concentration. Clinicians and dietitians should be aware of the risk of inadequate vitamin D status in pregnant women in the United States relative to their initial vitamin D status and the season of birth.
Entities:
Keywords:
insufficiency; pregnancy; season; supplements and functional foods; vitamin D
Authors: Lisa M Bodnar; Hyagriv N Simhan; Robert W Powers; Michael P Frank; Emily Cooperstein; James M Roberts Journal: J Nutr Date: 2007-02 Impact factor: 4.798
Authors: Lisa M Bodnar; Janet M Catov; Hyagriv N Simhan; Michael F Holick; Robert W Powers; James M Roberts Journal: J Clin Endocrinol Metab Date: 2007-05-29 Impact factor: 5.958
Authors: C R Gale; S M Robinson; N C Harvey; M K Javaid; B Jiang; C N Martyn; K M Godfrey; C Cooper Journal: Eur J Clin Nutr Date: 2007-02-21 Impact factor: 4.016
Authors: Cuilin Zhang; Chunfang Qiu; Frank B Hu; Robert M David; Rob M van Dam; Alexander Bralley; Michelle A Williams Journal: PLoS One Date: 2008-11-18 Impact factor: 3.240
Authors: Catherine Morgan; Linda Dodds; Donald B Langille; Hope A Weiler; B Anthony Armson; Jean-Claude Forest; Yves Giguère; Christy G Woolcott Journal: Arch Gynecol Obstet Date: 2015-09-24 Impact factor: 2.344
Authors: Daniel J Raiten; Alison L Steiber; Susan E Carlson; Ian Griffin; Diane Anderson; William W Hay; Sandra Robins; Josef Neu; Michael K Georgieff; Sharon Groh-Wargo; Tanis R Fenton Journal: Am J Clin Nutr Date: 2016-01-20 Impact factor: 7.045
Authors: Mengdi Lu; Augusto A Litonjua; George T O'Connor; Robert S Zeiger; Leonard Bacharier; Michael Schatz; Vincent J Carey; Scott T Weiss; Hooman Mirzakhani Journal: J Allergy Clin Immunol Date: 2020-08-19 Impact factor: 10.793
Authors: Sara Moukarzel; Marlies Ozias; Elizabeth Kerling; Danielle Christifano; Jo Wick; John Colombo; Susan Carlson Journal: Nutrients Date: 2018-01-23 Impact factor: 5.717
Authors: Devika Chawla; Julie L Daniels; Sara E Benjamin-Neelon; Bernard F Fuemmeler; Cathrine Hoyo; Jessie P Buckley Journal: J Nutr Sci Date: 2019-02-28
Authors: Fariba Aghajafari; Catherine J Field; Bonnie J Kaplan; Doreen M Rabi; Jack A Maggiore; Maeve O'Beirne; David A Hanley; Misha Eliasziw; Deborah Dewey; Amy Weinberg; Sue J Ross Journal: PLoS One Date: 2016-07-01 Impact factor: 3.240