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Literature DB >> 25302622

Investigation of single-drug-encapsulating liposomes using the nano-impact method.

Abstract

Encapsulating liposomes are widely used for controlled drug delivery. We report the use of nano-impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposomes and their picomolar concentration are also determined in biological buffer in real time.

Entities: Chemical

Keywords: drug delivery; electrochemistry; liposomes; nano-impact method; nanoparticles

Mesh：

Substances：
Drug Carriers
Liposomes

Year: 2014 PMID： 25302622 DOI： 10.1002/anie.201408934

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

17 in total

1. Electrochemical detection of a single cytomegalovirus at an ultramicroelectrode and its antibody anchoring.

Authors: Jeffrey E Dick; Adam T Hilterbrand; Aliaksei Boika; Jason W Upton; Allen J Bard
Journal: Proc Natl Acad Sci U S A Date: 2015-04-13 Impact factor: 11.205

2. Voltage-Gated Nanoparticle Transport and Collisions in Attoliter-Volume Nanopore Electrode Arrays.

Authors: Kaiyu Fu; Donghoon Han; Garrison M Crouch; Seung-Ryong Kwon; Paul W Bohn
Journal: Small Date: 2018-01-29 Impact factor: 13.281

3. Pharmacokinetic, biodistribution and therapeutic efficacy of 5-fluorouracil-loaded pH-sensitive PEGylated liposomal nanoparticles in HCT-116 tumor bearing mouse.

Authors: Ofonime Udofot; Kevin Affram; Taylor Smith; Bulumko Tshabe; Sunil Krishnan; Mandip Sachdeva; Edward Agyare
Journal: J Nat Sci Date: 2016

4. Quantitative measurement of transmitters in individual vesicles in the cytoplasm of single cells with nanotip electrodes.

Authors: Xianchan Li; Soodabeh Majdi; Johan Dunevall; Hoda Fathali; Andrew G Ewing
Journal: Angew Chem Int Ed Engl Date: 2015-08-12 Impact factor: 15.336

Review 5. Recent Advances in Voltammetry.

Authors: Christopher Batchelor-McAuley; Enno Kätelhön; Edward O Barnes; Richard G Compton; Eduardo Laborda; Angela Molina
Journal: ChemistryOpen Date: 2015-05-20 Impact factor: 2.911

Investigation of single-drug-encapsulating liposomes using the nano-impact method.

1. Electrochemical detection of a single cytomegalovirus at an ultramicroelectrode and its antibody anchoring.

2. Voltage-Gated Nanoparticle Transport and Collisions in Attoliter-Volume Nanopore Electrode Arrays.

3. Pharmacokinetic, biodistribution and therapeutic efficacy of 5-fluorouracil-loaded pH-sensitive PEGylated liposomal nanoparticles in HCT-116 tumor bearing mouse.

4. Quantitative measurement of transmitters in individual vesicles in the cytoplasm of single cells with nanotip electrodes.

Review 5. Recent Advances in Voltammetry.

Review 6. Advanced Nanoscale Approaches to Single-(Bio)entity Sensing and Imaging.

7. Enzymatically enhanced collisions on ultramicroelectrodes for specific and rapid detection of individual viruses.

8. Label-Free Detection of Single Living Bacteria via Electrochemical Collision Event.

9. Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer.

10. Electrochemical detection of single micelles through 'nano-impacts'.