Gaoxiang Ma1, Dongying Gu, Chunye Lv, Haiyan Chu, Zhi Xu, Na Tong, Meilin Wang, Cuiju Tang, Yong Xu, Zhengdong Zhang, Baolin Wang, Jinfei Chen. 1. Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Abstract
BACKGROUND AND AIM: Single nucleotide polymorphisms (SNPs) located in long noncoding RNA CASC8 gene may influence the process of splicing and stability of messenger RNA conformation, resulting in the modification of its interacting partners. Genome-wide association studies have identified the SNP rs10505477 and SNP rs1562430 in CASC8 were associated with risk of the colorectal cancer (CRC) and breast cancer, respectively. METHODS: In the present study, we genotyped the 940 surgically resected gastric cancer patients to explore the association between these two SNPs (e.g., rs10505477 and rs1562430) and survival of gastric cancer in a Chinese population. RESULTS: We found that the patients carrying rs10505477 GG genotype survived for a longer time than those with the GA and AA genotypes (log-rank P = 0.030). The similar result was also found in the dominant model (GA/AA vs GG, HR = 1.32, 95% CI = 1.08-1.63, log-rank P = 0.008). This risk effect was more pronounced among patients with tumor size ≤ 5 cm, diffuse-type gastric cancer, lymph node metastasis, no distant metastasis, and TNM stage III and IV. Furthermore, the area under the curve at five years was dramatically increased from 0.619 to 0.624 after adding the rs10505477 risk score to the traditional clinical risk score (TNM stage and lymph node metastasis). However, there was no association be found between the rs1562430 and the survival of gastric cancer. CONCLUSION: These findings suggested the SNP rs10505477 may contribute to the survival of gastric cancer and be a potential prognostic biomarker of gastric cancer.
BACKGROUND AND AIM: Single nucleotide polymorphisms (SNPs) located in long noncoding RNA CASC8 gene may influence the process of splicing and stability of messenger RNA conformation, resulting in the modification of its interacting partners. Genome-wide association studies have identified the SNP rs10505477 and SNP rs1562430 in CASC8 were associated with risk of the colorectal cancer (CRC) and breast cancer, respectively. METHODS: In the present study, we genotyped the 940 surgically resected gastric cancerpatients to explore the association between these two SNPs (e.g., rs10505477 and rs1562430) and survival of gastric cancer in a Chinese population. RESULTS: We found that the patients carrying rs10505477 GG genotype survived for a longer time than those with the GA and AA genotypes (log-rank P = 0.030). The similar result was also found in the dominant model (GA/AA vs GG, HR = 1.32, 95% CI = 1.08-1.63, log-rank P = 0.008). This risk effect was more pronounced among patients with tumor size ≤ 5 cm, diffuse-type gastric cancer, lymph node metastasis, no distant metastasis, and TNM stage III and IV. Furthermore, the area under the curve at five years was dramatically increased from 0.619 to 0.624 after adding the rs10505477 risk score to the traditional clinical risk score (TNM stage and lymph node metastasis). However, there was no association be found between the rs1562430 and the survival of gastric cancer. CONCLUSION: These findings suggested the SNP rs10505477 may contribute to the survival of gastric cancer and be a potential prognostic biomarker of gastric cancer.
Authors: Lei Hu; Shu-Hui Chen; Qiao-Li Lv; Bao Sun; Qiang Qu; Chong-Zhen Qin; Lan Fan; Ying Guo; Lin Cheng; Hong-Hao Zhou Journal: Int J Environ Res Public Health Date: 2016-05-30 Impact factor: 3.390
Authors: Maggie C Y Ng; Mariaelisa Graff; Yingchang Lu; Anne E Justice; Poorva Mudgal; Ching-Ti Liu; Kristin Young; Lisa R Yanek; Mary F Feitosa; Mary K Wojczynski; Kristin Rand; Jennifer A Brody; Brian E Cade; Latchezar Dimitrov; Qing Duan; Xiuqing Guo; Leslie A Lange; Michael A Nalls; Hayrettin Okut; Salman M Tajuddin; Bamidele O Tayo; Sailaja Vedantam; Jonathan P Bradfield; Guanjie Chen; Wei-Min Chen; Alessandra Chesi; Marguerite R Irvin; Badri Padhukasahasram; Jennifer A Smith; Wei Zheng; Matthew A Allison; Christine B Ambrosone; Elisa V Bandera; Traci M Bartz; Sonja I Berndt; Leslie Bernstein; William J Blot; Erwin P Bottinger; John Carpten; Stephen J Chanock; Yii-Der Ida Chen; David V Conti; Richard S Cooper; Myriam Fornage; Barry I Freedman; Melissa Garcia; Phyllis J Goodman; Yu-Han H Hsu; Jennifer Hu; Chad D Huff; Sue A Ingles; Esther M John; Rick Kittles; Eric Klein; Jin Li; Barbara McKnight; Uma Nayak; Barbara Nemesure; Adesola Ogunniyi; Andrew Olshan; Michael F Press; Rebecca Rohde; Benjamin A Rybicki; Babatunde Salako; Maureen Sanderson; Yaming Shao; David S Siscovick; Janet L Stanford; Victoria L Stevens; Alex Stram; Sara S Strom; Dhananjay Vaidya; John S Witte; Jie Yao; Xiaofeng Zhu; Regina G Ziegler; Alan B Zonderman; Adebowale Adeyemo; Stefan Ambs; Mary Cushman; Jessica D Faul; Hakon Hakonarson; Albert M Levin; Katherine L Nathanson; Erin B Ware; David R Weir; Wei Zhao; Degui Zhi; Donna K Arnett; Struan F A Grant; Sharon L R Kardia; Olufunmilayo I Oloapde; D C Rao; Charles N Rotimi; Michele M Sale; L Keoki Williams; Babette S Zemel; Diane M Becker; Ingrid B Borecki; Michele K Evans; Tamara B Harris; Joel N Hirschhorn; Yun Li; Sanjay R Patel; Bruce M Psaty; Jerome I Rotter; James G Wilson; Donald W Bowden; L Adrienne Cupples; Christopher A Haiman; Ruth J F Loos; Kari E North Journal: PLoS Genet Date: 2017-04-21 Impact factor: 6.020