Bharat Kumar Gupta1, Ranjan Solanki2, Himanshu Punia3, Vibhuti Agarwal4, Jaskiran Kaur5, Ashish Shukla5. 1. Professor, Department of Biochemistry, Subharti Medical College, Swami Vivakan and Subharti University , Meerut, India . 2. Associate Professor, Department of Pathology, Muzaffarnagar Medical College , Muzaffarnagar, India . 3. Reader, Department of Community Dentistry, Teerthankar Dental College , Moradabad, India . 4. Post Graduate Student, Department of Biochemistry, Subharti Medical College, Swami Vivakan and Subharti University , Meerut, India . 5. Assistant Professor, Department of Biochemistry, Subharti Medical College, Swami Vivakan and Subharti University , Meerut, India .
Abstract
INTRODUCTION: National Health and Nutrition Examination Survey (NHANES III), 1988-1994, first time reported a significant, positive association in iron storage and heart disease risk. Thereafter several researchers have found an association between iron overload, serum ferritin (SF) and MI. No such Indian study was available in the literature and so we decided to find out the relation of lipid profile and Serum Ferritin with myocardial infarction (MI). MATERIALS AND METHODS: Fifty indian patients of AMI (study group) and fifty indian healthy volunteers (control group) were included for the present study. Lipid profile including TC, HDL-c, LDL-c, VLDL-c & TG and SF levels were estimated in all subjects. OBSERVATIONS AND RESULTS: Mean ± SD of TC level was 250.64 ± 25.61, of HDL-c was 36.52 ± 2.86, of LDL-c was 165.69 ± 26.80, of VLDL-c was 42.35 ± 8.53 and of TG was 211.83 ± 42.65 in study group while these values were 174.46±47.68, 43.2±12.52, 98.37±41.13, 32.88±21.45 and 164.42±107.29 respectively in control group. All the parameters were found not only raised in patients of acute myocardial infarction (AMI) but were also statistically significant when compared with control group (p=<0.01). Mean ± SD of SF levels was 268.43±30.17 ng/ml in study group and 110.96±56.5 ng/ml in control group; this level was found not only raised in patients of AMI but were also statistically significant when compared with control group (p=<0.01). CONCLUSION: TC, LDL-c, VLDL-c, TG and SF levels were raised in patients of AMI and found to be statistically significant; while HDL-c levels were reduced in such patients and is also statistically significant. It can be concluded that there exists an association in lipid profile and SF with AMI therefore dyslipidemia and raised SF levels are the features of AMI.
INTRODUCTION: National Health and Nutrition Examination Survey (NHANES III), 1988-1994, first time reported a significant, positive association in iron storage and heart disease risk. Thereafter several researchers have found an association between iron overload, serum ferritin (SF) and MI. No such Indian study was available in the literature and so we decided to find out the relation of lipid profile and Serum Ferritin with myocardial infarction (MI). MATERIALS AND METHODS: Fifty indian patients of AMI (study group) and fifty indian healthy volunteers (control group) were included for the present study. Lipid profile including TC, HDL-c, LDL-c, VLDL-c & TG and SF levels were estimated in all subjects. OBSERVATIONS AND RESULTS: Mean ± SD of TC level was 250.64 ± 25.61, of HDL-c was 36.52 ± 2.86, of LDL-c was 165.69 ± 26.80, of VLDL-c was 42.35 ± 8.53 and of TG was 211.83 ± 42.65 in study group while these values were 174.46±47.68, 43.2±12.52, 98.37±41.13, 32.88±21.45 and 164.42±107.29 respectively in control group. All the parameters were found not only raised in patients of acute myocardial infarction (AMI) but were also statistically significant when compared with control group (p=<0.01). Mean ± SD of SF levels was 268.43±30.17 ng/ml in study group and 110.96±56.5 ng/ml in control group; this level was found not only raised in patients of AMI but were also statistically significant when compared with control group (p=<0.01). CONCLUSION:TC, LDL-c, VLDL-c, TG and SF levels were raised in patients of AMI and found to be statistically significant; while HDL-c levels were reduced in such patients and is also statistically significant. It can be concluded that there exists an association in lipid profile and SF with AMI therefore dyslipidemia and raised SF levels are the features of AMI.
Entities:
Keywords:
Acute myocardial infarction; Indian population; Lipid profile; Serum ferritin
Authors: K Klipstein-Grobusch; J F Koster; D E Grobbee; J Lindemans; H Boeing; A Hofman; J C Witteman Journal: Am J Clin Nutr Date: 1999-06 Impact factor: 7.045
Authors: Umesh N Khot; Monica B Khot; Christopher T Bajzer; Shelly K Sapp; E Magnus Ohman; Sorin J Brener; Stephen G Ellis; A Michael Lincoff; Eric J Topol Journal: JAMA Date: 2003-08-20 Impact factor: 56.272
Authors: S Kiechl; F Aichner; F Gerstenbrand; G Egger; A Mair; G Rungger; F Spögler; E Jarosch; F Oberhollenzer; J Willeit Journal: Arterioscler Thromb Date: 1994-10