Literature DB >> 2530159

Antigen-specific inhibition of IL-2 and IL-3 production in contact sensitivity to TNP.

J Marcinkiewicz1, B Chain.   

Abstract

The production of IL-2 and IL-3 by T cells from mice which had been contact sensitized to TNP and/or tolerized by intravenous injections of TNBS was assayed. Contact sensitization rapidly primes T cells, so that they respond to in vitro restimulation with haptenated syngeneic cells by producing IL-2 and IL-3. This production is strongly inhibited, in an antigen-specific manner, in tolerized mice. At least part of this inhibition can be attributed to the action of suppressor T cells that act by preventing the activation of lymphokine production in vitro. Lymphokine production thus closely parallels the in vivo delayed-type hypersensitivity (DTH) reaction in this system.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2530159      PMCID： PMC1385414     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  16 in total

Review 1.  An overview of T-suppressor cell circuits.

Authors:  G L Asherson; V Colizzi; M Zembala
Journal:  Annu Rev Immunol       Date:  1986       Impact factor: 28.527

2.  Delayed-type hypersensitivity is mediated by a sequence of two different T cell activities.

Authors:  H Van Loveren; P W Askenase
Journal:  J Immunol       Date:  1984-11       Impact factor: 5.422

3.  Dendritic cells and the initiation of contact sensitivity to fluorescein isothiocyanate.

Authors:  S E Macatonia; A J Edwards; S C Knight
Journal:  Immunology       Date:  1986-12       Impact factor: 7.397

4.  The induction of oxazolone-specific T suppressor afferent cells in mice by hapten-modified isologous IgG.

Authors:  J Marcinkiewicz; M Bereta; J Malinowski; W Ptak
Journal:  Eur J Immunol       Date:  1984-08       Impact factor: 5.532

5.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Authors:  T R Mosmann; H Cherwinski; M W Bond; M A Giedlin; R L Coffman
Journal:  J Immunol       Date:  1986-04-01       Impact factor: 5.422

6.  Selective production of interleukin 3 (IL3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in vitro by murine L3T4+ T cells: lack of spontaneous IL3 and GM-CSF production by Ly-2-/L3T4- lpr subset.

Authors:  J L Davignon; M Kimoto; V Kindler; S De Kossodo; P Vassalli; S Izui
Journal:  Eur J Immunol       Date:  1988-09       Impact factor: 5.532

7.  Suppression of interleukin-2 production by macrophages in genetically susceptible mice infected with Leishmania major.

Authors:  E Cillari; F Y Liew; R Lelchuk
Journal:  Infect Immun       Date:  1986-11       Impact factor: 3.441

8.  An improved colorimetric assay for interleukin 2.

Authors:  H Tada; O Shiho; K Kuroshima; M Koyama; K Tsukamoto
Journal:  J Immunol Methods       Date:  1986-11-06       Impact factor: 2.303

9.  Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

Authors:  J R Lamb; B J Skidmore; N Green; J M Chiller; M Feldmann
Journal:  J Exp Med       Date:  1983-05-01       Impact factor: 14.307

10.  Regulation of delayed hypersensitivity. Failure to transfer delayed hypersensitivity to desensitized guinea pigs.

Authors:  J M Dwyer; F S Kantor
Journal:  J Exp Med       Date:  1973-01-01       Impact factor: 14.307
View more
  6 in total

1.  Conjugates of COL-1 monoclonal antibody and beta-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug beta-D-galactosyl-5-fluorouridine.

Authors:  R Abraham; N Aman; R von Borstel; M Darsley; B Kamireddy; J Kenten; G Morris; R Titmas
Journal:  Cell Biophys       Date:  1994

2.  Antigen-specific and non-specific depression of proliferative responses induced during contact sensitivity in mice.

Authors:  D Baker; I Kimber; K Ahmed; J L Turk
Journal:  Int J Exp Pathol       Date:  1991-02       Impact factor: 1.925

3.  Contact sensitization to oxazolone: involvement of both interferon-gamma and interleukin-4 in oxazolone-specific Ig and T-cell responses.

Authors:  J A Thomson; A B Troutt; A Kelso
Journal:  Immunology       Date:  1993-02       Impact factor: 7.397

4.  Regulated production of a pleiotropic cytokine-platelet-derived growth factor--by differentiating erythroid cells in vitro and in vivo.

Authors:  J C Keutzer; A J Sytkowski
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205

5.  The kinetics of cytokine production by draining lymph node cells following primary exposure of mice to chemical allergens.

Authors:  J C Hope; R J Dearman; I Kimber; S J Hopkins
Journal:  Immunology       Date:  1994-10       Impact factor: 7.397

6.  Differential regulation of cytokine production by nitric oxide.

Authors:  J Marcinkiewicz; B M Chain
Journal:  Immunology       Date:  1993-09       Impact factor: 7.397
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.