Devi Dayal1, Hemant Jain2, Savita Verma Attri1, Bhavneet Bharti1, Anil Kumar Bhalla3. 1. Associate Professor, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research , Chandigarh, India . 2. Registrar, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research , Chandigarh, India . 3. Professor, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
Abstract
CONTEXT: High senstivity C-reactive protein (hsCRP) levels correlate well other parameters of obesity related metabolic syndrome (MS) and can be used as predictors of future cardiovascular disease risk. There is limited data on hsCRP levels in Indian children with simple obesity. AIM: To study the relationship of hsCRP levels with various anthropometric as well as metabolic parameters in children with simple overweight and obesity. MATERIALS AND METHODS: This case control study was conducted in Paediatric Endocrinology clinic of a tertiary care hospital in Northern India. Levels of hsCRP were estimated in 100 overweight and obese children (BMI between 85(th) and 95(th) percentiles according to age & gender specific CDC 2000 growth charts) aged between 6 and 16 years and in 100 nearly age and sex matched healthy controls. These levels were then correlated to various anthropometric (body mass index, BMI; waist circumference, WC; hip circumference, HC; waist hip ratio, WHR; blood pressure) and biochemical (fasting blood glucose, FBG; total cholesterol, TC; high-density lipoprotein-cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; very low-density lipoprotein-cholesterol, VLDL-C; triglycerides, TG) parameters. RESULTS: Mean levels of hsCRP were significantly higher in the study group (3.92±2.20 versus 2.15±1.05 mg/L) as compared to controls. Significantly more (58% versus 10%) subjects in the study group had hsCRP (>3 mg/L). Of all the parameters studied, only BMI showed a positive correlation with hsCRP levels in the study group. Multiple logistic regression analysis for predicting outcome of high hsCRP showed positive correlation with BMI; with every 1 kg/m(2) increase in BMI, odds of high hsCRP level were increased by 37% (OR=1.37; 95% CI 1.23-1.53, p-value <0.0001). Mean values of all the biochemical parameters except HDL-C were significantly higher in the study group. CONCLUSION: Levels of hsCRP were significantly elevated in overweight and obese children as compared to non-obese children. In addition, these patients also showed abnormalities of lipid and glucose metabolism.
CONTEXT: High senstivity C-reactive protein (hsCRP) levels correlate well other parameters of obesity related metabolic syndrome (MS) and can be used as predictors of future cardiovascular disease risk. There is limited data on hsCRP levels in Indian children with simple obesity. AIM: To study the relationship of hsCRP levels with various anthropometric as well as metabolic parameters in children with simple overweight and obesity. MATERIALS AND METHODS: This case control study was conducted in Paediatric Endocrinology clinic of a tertiary care hospital in Northern India. Levels of hsCRP were estimated in 100 overweight and obesechildren (BMI between 85(th) and 95(th) percentiles according to age & gender specific CDC 2000 growth charts) aged between 6 and 16 years and in 100 nearly age and sex matched healthy controls. These levels were then correlated to various anthropometric (body mass index, BMI; waist circumference, WC; hip circumference, HC; waist hip ratio, WHR; blood pressure) and biochemical (fasting blood glucose, FBG; total cholesterol, TC; high-density lipoprotein-cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; very low-density lipoprotein-cholesterol, VLDL-C; triglycerides, TG) parameters. RESULTS: Mean levels of hsCRP were significantly higher in the study group (3.92±2.20 versus 2.15±1.05 mg/L) as compared to controls. Significantly more (58% versus 10%) subjects in the study group had hsCRP (>3 mg/L). Of all the parameters studied, only BMI showed a positive correlation with hsCRP levels in the study group. Multiple logistic regression analysis for predicting outcome of high hsCRP showed positive correlation with BMI; with every 1 kg/m(2) increase in BMI, odds of high hsCRP level were increased by 37% (OR=1.37; 95% CI 1.23-1.53, p-value <0.0001). Mean values of all the biochemical parameters except HDL-C were significantly higher in the study group. CONCLUSION: Levels of hsCRP were significantly elevated in overweight and obesechildren as compared to non-obesechildren. In addition, these patients also showed abnormalities of lipid and glucose metabolism.
Authors: R J Kuczmarski; C L Ogden; L M Grummer-Strawn; K M Flegal; S S Guo; R Wei; Z Mei; L R Curtin; A F Roche; C L Johnson Journal: Adv Data Date: 2000-06-08
Authors: Patricio López-Jaramillo; Elizabeth Herrera; Ronald G Garcia; Paul A Camacho; Victor R Castillo Journal: Am J Hypertens Date: 2008-03-06 Impact factor: 2.689
Authors: Rachel M Burke; Parminder S Suchdev; Paulina A Rebolledo; Anna M Fabiszewski de Aceituno; Rita Revollo; Volga Iñiguez; Mitchel Klein; Carolyn Drews-Botsch; Juan S Leon Journal: Am J Trop Med Hyg Date: 2016-08-15 Impact factor: 2.345
Authors: Luz Elena Ramos-Arellano; Ines Matia-Garcia; Linda Anahi Marino-Ortega; Natividad Castro-Alarcón; José Francisco Muñoz-Valle; Lorenzo Salgado-Goytia; Aralia Berenice Salgado-Bernabé; Isela Parra-Rojas Journal: J Int Med Res Date: 2020-12 Impact factor: 1.671