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Literature DB >> 25300511

Very large common fragile site genes and their potential role in cancer development.

Abstract

Common fragile sites (CFSs) are large chromosomal regions that are hot-spots for alterations especially within cancer cells. The three most frequently expressed CFS regions (FRA3B, FRA16D and FRA6E) contain genes that span extremely large genomic regions (FHIT, WWOX and PARK2, respectively), and these genes were found to function as important tumor suppressors. Many other CFS regions contain extremely large genes that are also targets of alterations in multiple cancers, but none have yet been demonstrated to function as tumor suppressors. The loss of expression of just FHIT or WWOX has been found to be associated with a worse overall clinical outcome. Studies in different cancers have revealed that some cancers have decreased expression of multiple large CFS genes. This loss of expression could have a profound phenotypic effect on these cells. In this review, we will summarize the known large common fragile site genes and discuss their potential relationship to cancer development.

Entities: Disease Gene

Mesh：

Year: 2014 PMID： 25300511 DOI： 10.1007/s00018-014-1753-6

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

112 in total

1. Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.

Authors: Anne Helmrich; Monica Ballarino; Laszlo Tora
Journal: Mol Cell Date: 2011-12-23 Impact factor: 17.970

2. The effects of oxidative stress on parkin and other E3 ligases.

Authors: Matthew J LaVoie; Giuseppe P Cortese; Beth L Ostaszewski; Michael G Schlossmacher
Journal: J Neurochem Date: 2007-09-19 Impact factor: 5.372

3. Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma.

Authors: Q Yang; G Yoshimura; T Suzuma; T Tamaki; T Umemura; M Nakamura; Y Nakamura; X Wang; I Mori; T Sakurai; K Kakudo
Journal: Clin Cancer Res Date: 2001-12 Impact factor: 12.531

4. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.

Authors: K M Fong; E J Biesterveld; A Virmani; I Wistuba; Y Sekido; S A Bader; M Ahmadian; S T Ong; F V Rassool; P V Zimmerman; G Giaccone; A F Gazdar; J D Minna
Journal: Cancer Res Date: 1997-06-01 Impact factor: 12.701

5. Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin.

Authors: J Dai; P T Ram; L Yuan; L L Spriggs; S M Hill
Journal: Mol Cell Endocrinol Date: 2001-05-15 Impact factor: 4.102

6. The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers.

Authors: Bruce C Turner; Michelle Ottey; Drazen B Zimonjic; Magdalena Potoczek; Walter W Hauck; Edward Pequignot; Catherine L Keck-Waggoner; Cinzia Sevignani; C Marcelo Aldaz; Peter A McCue; Juan Palazzo; Kay Huebner; Nicholas C Popescu
Journal: Cancer Res Date: 2002-07-15 Impact factor: 12.701

7. Loss of FHIT protein expression is related to high proliferation, low apoptosis and worse prognosis in non-small-cell lung cancer.

Authors: Gemma Toledo; Jesús Javier Sola; Maria Dolores Lozano; Elena Soria; Javier Pardo
Journal: Mod Pathol Date: 2004-04 Impact factor: 7.842

8. Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.

Authors: Hideshi Ishii; Andrea Vecchione; Yutaka Furukawa; Krittaya Sutheesophon; Shuang-Yin Han; Teresa Druck; Tamotsu Kuroki; Francesco Trapasso; Miki Nishimura; Yasushi Saito; Keiya Ozawa; Carlo M Croce; Kay Huebner; Yusuke Furukawa
Journal: Mol Cancer Res Date: 2003-11 Impact factor: 5.852

9. Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features.

Authors: Mark Bloomston; Jeffrey Kneile; Matthew Butterfield; Mary Dillhoff; Peter Muscarella; E Christopher Ellison; W Scott Melvin; Carlo M Croce; Flavia Pichiorri; Kay Huebner; Wendy L Frankel
Journal: Ann Surg Oncol Date: 2009-05-12 Impact factor: 5.344

10. Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.

Authors: Francesco Trapasso; Flavia Pichiorri; Marco Gaspari; Tiziana Palumbo; Rami I Aqeilan; Eugenio Gaudio; Hiroshi Okumura; Rodolfo Iuliano; Giampiero Di Leva; Muller Fabbri; David E Birk; Cinzia Raso; Kari Green-Church; Luigi G Spagnoli; Salvatore Venuta; Kay Huebner; Carlo M Croce
Journal: J Biol Chem Date: 2008-03-03 Impact factor: 5.157

25 in total

Review 1. The role of fork stalling and DNA structures in causing chromosome fragility.

Authors: Simran Kaushal; Catherine H Freudenreich
Journal: Genes Chromosomes Cancer Date: 2019-01-29 Impact factor: 5.006

2. Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance.

Authors: Hiroshi Handa; Yoshiko Sasaki; Hikaru Hattori; Lobna Alkebsi; Tetsuhiro Kasamatsu; Takayuki Saitoh; Takeki Mitsui; Akihiko Yokohama; Norifumi Tsukamoto; Morio Matsumoto; Hirokazu Murakami
Journal: Oncol Lett Date: 2017-07-26 Impact factor: 2.967

Very large common fragile site genes and their potential role in cancer development.

1. Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.

2. The effects of oxidative stress on parkin and other E3 ligases.

3. Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma.

4. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.

5. Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin.

6. The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers.

7. Loss of FHIT protein expression is related to high proliferation, low apoptosis and worse prognosis in non-small-cell lung cancer.

8. Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.

9. Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features.

10. Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.

Review 1. The role of fork stalling and DNA structures in causing chromosome fragility.

2. Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance.

Review 3. Fragile sites in cancer: more than meets the eye.

4. [HPV-associated head and neck cancer : mutational signature and genomic aberrations].

Review 5. Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells.

6. FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells.

7. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.

8. Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster.

9. WWOX modulates the ATR-mediated DNA damage checkpoint response.

10. Genomic mechanisms underlying PARK2 large deletions identified in a cohort of patients with PD.