Literature DB >> 25299867

Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.

P A Minchella1, A E Armitage2, B Darboe3, M W Jallow3, H Drakesmith2, A Jaye3, A M Prentice4, J M McDermid1.   

Abstract

Hepcidin inhibits ferroportin-mediated iron efflux, leading to intracellular macrophage iron retention, possibly favoring Mycobacterium tuberculosis iron acquisition and tuberculosis (TB) pathogenesis. Plasma hepcidin was measured at human immunodeficiency virus (HIV) diagnosis in a retrospective HIV-prevalent, antiretroviral-naïve African cohort to investigate the association with incident pulmonary and/or extra-pulmonary TB. One hundred ninety-six participants were followed between 5 August 1992 and 1 June 2002, with 32 incident TB cases identified. Greater hepcidin was associated with significantly increased likelihood of TB after a median time to TB of 6 months. Elucidation of iron-related causal mechanisms and time-sensitive biomarkers that identify individual changes in TB risk are needed.

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Year:  2014        PMID： 25299867     DOI： 10.5588/ijtld.14.0143

Source DB:  PubMed          Journal:  Int J Tuberc Lung Dis        ISSN： 1027-3719            Impact factor:   2.373


  12 in total

1.  Modulation of iron status biomarkers in tuberculosis-diabetes co-morbidity.

Authors:  Nathella Pavan Kumar; Vaithilingam V Banurekha; Dina Nair; Chandrakumar Dolla; Paul Kumaran; Subash Babu
Journal:  Tuberculosis (Edinb)       Date:  2017-11-24       Impact factor: 3.131

2.  Anemia, Iron Status, and HIV: A Systematic Review of the Evidence.

Authors:  Ajibola I Abioye; Christopher T Andersen; Christopher R Sudfeld; Wafaie W Fawzi
Journal:  Adv Nutr       Date:  2020-09-01       Impact factor: 8.701

3.  HIV-Associated Tuberculosis: Does the Iron-Regulatory Hormone Hepcidin Connect Anemia With Poor Prognosis?

Authors:  Andrew E Armitage; Ed Moran
Journal:  J Infect Dis       Date:  2015-07-01       Impact factor: 5.226

4.  Elevated Hepcidin Is Part of a Complex Relation That Links Mortality with Iron Homeostasis and Anemia in Men and Women with HIV Infection.

Authors:  Peter A Minchella; Andrew E Armitage; Bakary Darboe; Momodou W Jallow; Hal Drakesmith; Assan Jaye; Andrew M Prentice; Joann M McDermid
Journal:  J Nutr       Date:  2015-04-22       Impact factor: 4.798

5.  Relationship Between Blood Concentrations of Hepcidin and Anemia Severity, Mycobacterial Burden, and Mortality Among Patients With HIV-Associated Tuberculosis.

Authors:  Andrew D Kerkhoff; Graeme Meintjes; Rosie Burton; Monica Vogt; Robin Wood; Stephen D Lawn
Journal:  J Infect Dis       Date:  2015-07-01       Impact factor: 5.226

6.  Hepcidin deficiency and iron deficiency do not alter tuberculosis susceptibility in a murine M.tb infection model.

Authors:  Rachel Harrington-Kandt; Elena Stylianou; Lucy A Eddowes; Pei Jin Lim; Lisa Stockdale; Nawamin Pinpathomrat; Naomi Bull; Janet Pasricha; Marta Ulaszewska; Yulia Beglov; Sophie Vaulont; Hal Drakesmith; Helen McShane
Journal:  PLoS One       Date:  2018-01-11       Impact factor: 3.240

7.  The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia.

Authors:  Eugenia Quiros-Roldan; Francesco Castelli; Paola Lanza; Chiara Pezzoli; Marika Vezzoli; Giorgio Biasiotto; Isabella Zanella
Journal:  J Transl Med       Date:  2017-12-19       Impact factor: 5.531

8.  Ironing out sex differences in tuberculosis prevalence.

Authors:  Tom A Yates; Sarah H Atkinson
Journal:  Int J Tuberc Lung Dis       Date:  2017-05-01       Impact factor: 2.373

9.  Differences in response to antiretroviral therapy in HIV-positive patients being treated for tuberculosis in Eastern Europe, Western Europe and Latin America.

Authors:  Yanink Caro-Vega; Anna Schultze; Anne Marie W Efsen; Frank A Post; Alexander Panteleev; Aliaksandr Skrahin; Jose M Miro; Enrico Girardi; Daria N Podlekareva; Jens D Lundgren; Juan Sierra-Madero; Javier Toibaro; Jaime Andrade-Villanueva; Simona Tetradov; Jan Fehr; Joan Caylà; Marcelo H Losso; Robert F Miller; Amanda Mocroft; Ole Kirk; Brenda Crabtree-Ramírez
Journal:  BMC Infect Dis       Date:  2018-04-23       Impact factor: 3.090

10.  Immunological non-response and low hemoglobin levels are predictors of incident tuberculosis among HIV-infected individuals on Truvada-based therapy in Botswana.

Authors:  Lucy Mupfumi; Sikhulile Moyo; Kesaobaka Molebatsi; Prisca K Thami; Motswedi Anderson; Tuelo Mogashoa; Thato Iketleng; Joseph Makhema; Richard Marlink; Ishmael Kasvosve; Max Essex; Rosemary M Musonda; Simani Gaseitsiwe
Journal:  PLoS One       Date:  2018-01-31       Impact factor: 3.240
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