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Literature DB >> 25297652

The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.

Sarah K Casper¹, Scott J Schoeller, Danielle M Zgoba, Andrew J Phillips, Thomas J Morien, Gary R Chaffee, Peter C Sackett, Francis C Peterson, Kirsten Crossgrove, Christopher T Veldkamp.

Abstract

Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins.

Entities: Chemical Disease Gene Species

Keywords: Brugia malayi; Caenorhabditis elegans; DAF-16; FOXO; FOXO1; FOXO3a; FOXO4; filariasis; forkhead box; insulin-signaling pathway; winged helix

Mesh：

Substances：

Year: 2014 PMID： 25297652 PMCID： PMC4809524 DOI： 10.1002/prot.24701

Source DB: PubMed Journal: Proteins ISSN： 0887-3585

26 in total

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Authors: J Weigelt; I Climent; K Dahlman-Wright; M Wikström
Journal: Biochemistry Date: 2001-05-22 Impact factor: 3.162

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Authors: Torsten Herrmann; Peter Güntert; Kurt Wüthrich
Journal: J Mol Biol Date: 2002-05-24 Impact factor: 5.469

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Authors: John L Markley; Eldon L Ulrich; William M Westler; Brian F Volkman
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Authors: T R Bürglin; E Lobos; M L Blaxter
Journal: Int J Parasitol Date: 1998-03 Impact factor: 3.981

Review 6. Worming pathways to and from DAF-16/FOXO.

Authors: Arnab Mukhopadhyay; Seung Wook Oh; Heidi A Tissenbaum
Journal: Exp Gerontol Date: 2006-07-12 Impact factor: 4.032

7. NMRPipe: a multidimensional spectral processing system based on UNIX pipes.

Authors: F Delaglio; S Grzesiek; G W Vuister; G Zhu; J Pfeifer; A Bax
Journal: J Biomol NMR Date: 1995-11 Impact factor: 2.835

8. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.

Authors: T Furuyama; T Nakazawa; I Nakano; N Mori
Journal: Biochem J Date: 2000-07-15 Impact factor: 3.857

The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.

1. Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4).

2. Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA.

3. The Xplor-NIH NMR molecular structure determination package.

Review 4. Macromolecular structure determination by NMR spectroscopy.

Review 5. Caenorhabditis elegans as a model for parasitic nematodes.

Review 6. Worming pathways to and from DAF-16/FOXO.

7. NMRPipe: a multidimensional spectral processing system based on UNIX pipes.

8. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.

9. Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.

10. Transgenic C. elegans dauer larvae expressing hookworm phospho null DAF-16/FoxO exit dauer.

1. Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression.

2. Characterization of innate immunity genes in the parasitic nematode Brugia malayi.