Literature DB >> 25296889

Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme.

Carlos Roberto Alves1, Bernardo Acácio Santini Pereira, Mariana Silva-Almeida, Franklin Souza da Silva.   

Abstract

The use of proteinases as targets to develop novel chemotherapies against Leishmania spp. infections is a very promising strategy. Based on a previous study by Goyal et al. [J Mol Model (2014) 20:2099], we discuss herein the idea that only a combined treatment with distinct proteinase inhibitors would be an effective antileishmanial therapy.

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Year:  2014        PMID： 25296889     DOI： 10.1007/s00894-014-2465-4

Source DB:  PubMed          Journal:  J Mol Model        ISSN： 0948-5023            Impact factor:   1.810


  34 in total

1.  Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta.

Authors:  Ashwini Somanna; Vasanthakrishna Mundodi; Lashitew Gedamu
Journal:  J Biol Chem       Date:  2002-05-08       Impact factor: 5.157

2.  Recent Developments in Leishmaniasis: Epidemiology, Diagnosis, and Treatment.

Authors:  Jonathan Berman
Journal:  Curr Infect Dis Rep       Date:  2005-01       Impact factor: 3.725

3.  Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.

Authors:  Parag P Shah; Michael C Myers; Mary Pat Beavers; Jeremy E Purvis; Huiyan Jing; Heather J Grieser; Elizabeth R Sharlow; Andrew D Napper; Donna M Huryn; Barry S Cooperman; Amos B Smith; Scott L Diamond
Journal:  Mol Pharmacol       Date:  2008-04-10       Impact factor: 4.436

4.  Mechanistic insights into mode of actions of novel oligopeptidase B inhibitors for combating leishmaniasis.

Authors:  Sukriti Goyal; Sonam Grover; Jaspreet Kaur Dhanjal; Manisha Goyal; Chetna Tyagi; Sajeev Chacko; Abhinav Grover
Journal:  J Mol Model       Date:  2014-02-25       Impact factor: 1.810

5.  Structure of antipain, a new Sakaguchi-positive product of streptomyces.

Authors:  S Umezawa; K Tatsuta; K Fujimoto; T Tsuchiya; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1972-04       Impact factor: 2.649

6.  Effects of HIV aspartyl-proteinase inhibitors on Leishmania sp.

Authors:  Elizabeth Valdivieso; Ariadne Rangel; Javier Moreno; Jose María Saugar; Carmen Cañavate; Jorge Alvar; Francehuli Dagger
Journal:  Exp Parasitol       Date:  2010-06-08       Impact factor: 2.011

7.  Oligopeptidase B deficient mutants of Leishmania major.

Authors:  Jane C Munday; Karen McLuskey; Elaine Brown; Graham H Coombs; Jeremy C Mottram
Journal:  Mol Biochem Parasitol       Date:  2010-09-29       Impact factor: 1.759

8.  Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.

Authors:  Prashant V Desai; Akshay Patny; Yogesh Sabnis; Babu Tekwani; Jiri Gut; Philip Rosenthal; Anuradha Srivastava; Mitchell Avery
Journal:  J Med Chem       Date:  2004-12-16       Impact factor: 7.446

9.  Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity.

Authors:  Saulo C Bourguignon; Danielle F B Cavalcanti; Alessandra M T de Souza; Helena C Castro; Carlos R Rodrigues; Magaly G Albuquerque; Dilvani O Santos; Gabriel Gomes da Silva; Fernando C da Silva; Vitor F Ferreira; Rosa T de Pinho; Carlos R Alves
Journal:  Exp Parasitol       Date:  2010-07-18       Impact factor: 2.132

10.  Overview of the organization of protease genes in the genome of Leishmania spp.

Authors:  Mariana Silva-Almeida; Franklin Souza-Silva; Bernardo Acácio Santini Pereira; Michelle Lopes Ribeiro-Guimarães; Carlos Roberto Alves
Journal:  Parasit Vectors       Date:  2014-08-20       Impact factor: 3.876
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  2 in total

1.  Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite.

Authors:  Franklin Souza-Silva; Saulo Cabral Bourguignon; Bernardo Acácio Santini Pereira; Luzia Monteiro de Castro Côrtes; Luiz Filipe Gonçalves de Oliveira; Andrea Henriques-Pons; Lea Cysne Finkelstein; Vitor Francisco Ferreira; Paula Fernandes Carneiro; Rosa Teixeira de Pinho; Ernesto Raul Caffarena; Carlos Roberto Alves
Journal:  Antimicrob Agents Chemother       Date:  2015-01-12       Impact factor: 5.191

2.  Dipeptidyl peptidase 3, a novel protease from Leishmania braziliensis.

Authors:  Jenny R Diaz; Cesar A Ramírez; Paola A Nocua; Fanny Guzman; José M Requena; Concepción J Puerta
Journal:  PLoS One       Date:  2018-01-05       Impact factor: 3.240
  2 in total

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