OBJECTIVE: This study was designed to examine the relevance of single-nucleotide polymorphism (SNP) rs11212617 with treatment success in type 2 diabetes patients from Shanghai local Chinese Han population. METHODS: We genotyped rs11212617 in incident metformin users of type 2 diabetes patients from Shanghai local Chinese Han population. Association between rs11212617 and changes in HbA1c, fasting plasma glucose and postprandial glucose level were analysed. RESULTS: Two hundred and seventy-four incident metformin users were included in the study sample. The SNP rs11212617 was significantly associated with metformin response in Shanghai local Chinese Han population. CONCLUSION: The rs11212617 is associated with a reduction in HbA1c, fasting plasma glucose and postprandial glucose level. These results suggest that metformin treatment may be more efficacious in Shanghai and valuable for Chinese daily clinical practice.
OBJECTIVE: This study was designed to examine the relevance of single-nucleotide polymorphism (SNP) rs11212617 with treatment success in type 2 diabetespatients from Shanghai local Chinese Han population. METHODS: We genotyped rs11212617 in incident metformin users of type 2 diabetespatients from Shanghai local Chinese Han population. Association between rs11212617 and changes in HbA1c, fasting plasma glucose and postprandial glucose level were analysed. RESULTS: Two hundred and seventy-four incident metformin users were included in the study sample. The SNP rs11212617 was significantly associated with metformin response in Shanghai local Chinese Han population. CONCLUSION: The rs11212617 is associated with a reduction in HbA1c, fasting plasma glucose and postprandial glucose level. These results suggest that metformin treatment may be more efficacious in Shanghai and valuable for Chinese daily clinical practice.
Authors: Moataz E Mohamed; David P Schladt; Weihua Guan; Baolin Wu; Jessica van Setten; Brendan J Keating; David Iklé; Rory P Remmel; Casey R Dorr; Roslyn B Mannon; Arthur J Matas; Ajay K Israni; William S Oetting; Pamala A Jacobson Journal: Am J Transplant Date: 2019-05-13 Impact factor: 8.086
Authors: Yulia A Nasykhova; Yury A Barbitoff; Ziravard N Tonyan; Maria M Danilova; Ivan A Nevzorov; Tatiana M Komandresova; Anastasiia A Mikhailova; Tatiana V Vasilieva; Olga B Glavnova; Maria I Yarmolinskaya; Evgenia I Sluchanko; Andrey S Glotov Journal: Genes (Basel) Date: 2022-07-23 Impact factor: 4.141
Authors: Yulia A Nasykhova; Ziravard N Tonyan; Anastasiia A Mikhailova; Maria M Danilova; Andrey S Glotov Journal: Int J Mol Sci Date: 2020-09-18 Impact factor: 5.923