Response to Lilienfield.

The article by Lillienfeld in this issue comprises a thoughtful critique of the Research Domain Criteria (RDoC) project initiated by the National Institute of Mental Health, and includes four specific theoretical and methodological challenges along with recommendations to address each one. In this commentary, I briefly consider each of the four challenges in turn, noting points of agreement and also clarifying selected points from the NIMH RDoC perspective. Overall, Lillienfeld's paper represents a valuable contribution to the RDoC literature as research conducted with the new framework continues to accelerate. Published by Elsevier Ltd.