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Literature DB >> 2529443

Light-dark differences in [3H]-paroxetine binding to rabbit platelet membranes.

Abstract

[3H]-Paroxetine binding to rabbit blood platelet membranes from samples obtained under light and dark conditions was examined. Animals were kept on a 14 h light (L) - 10 h dark (D) schedule and blood samples were collected at L + 7 and D + 5 h. Significant differences were found for Bmax values of [3H]-paroxetine binding, with low Bmax values during the light period and high Bmax values during the dark period. The Kd values were not significantly different. These results confirm previous observations on light-dark differences of [3H]-imipramine binding in rabbit blood platelets suggesting the existence of a circadian rhythm for the 5-HT transporter complex.

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Year: 1989 PMID： 2529443 DOI： 10.1007/bf00169205

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

23 in total

1. Reduced Bmax of [3H]-imipramine binding to platelets of depressed patients free of previous medication with 5HT uptake inhibitors.

Authors: M F Poirier; C Benkelfat; H Loo; D Sechter; E Zarifian; A M Galzin; S Z Langer
Journal: Psychopharmacology (Berl) Date: 1986 Impact factor: 4.530

2. Effect of different photoperiod exposure on [3H]imipramine binding and serotonin uptake in the rat brain.

Authors: A C Rovescalli; N Brunello; M Riva; R Galimberti; G Racagni
Journal: J Neurochem Date: 1989-02 Impact factor: 5.372

3. Circadian rhythm of serotonin transport in human platelets.

Authors: I Modai; R Malmgren; M Asberg; H Beving
Journal: Psychopharmacology (Berl) Date: 1986 Impact factor: 4.530

4. A simplification of the protein assay method of Lowry et al. which is more generally applicable.

Authors: G L Peterson
Journal: Anal Biochem Date: 1977-12 Impact factor: 3.365

5. Association of [3H]-imipramine and [3H]-paroxetine binding with the 5HT transporter in brain and platelets: relevance to studies in depression.

Authors: S Z Langer; A M Galzin; M F Poirier; H Loo; D Sechter; E Zarifian
Journal: J Recept Res Date: 1987

6. Serotonin modulates the dissociation of [3H]imipramine from human platelet recognition sites.

Authors: L P Wennogle; L R Meyerson
Journal: Eur J Pharmacol Date: 1982-12-24 Impact factor: 4.432

7. Imipramine binding site. Temperature dependence of the binding of 3H-labeled imipramine and 3H-labeled paroxetine to human platelet membrane.

Authors: P Plenge; E T Mellerup
Journal: Biochim Biophys Acta Date: 1984-02-29

Light-dark differences in [3H]-paroxetine binding to rabbit platelet membranes.

1. Reduced Bmax of [3H]-imipramine binding to platelets of depressed patients free of previous medication with 5HT uptake inhibitors.

2. Effect of different photoperiod exposure on [3H]imipramine binding and serotonin uptake in the rat brain.

3. Circadian rhythm of serotonin transport in human platelets.

4. A simplification of the protein assay method of Lowry et al. which is more generally applicable.

5. Association of [3H]-imipramine and [3H]-paroxetine binding with the 5HT transporter in brain and platelets: relevance to studies in depression.

6. Serotonin modulates the dissociation of [3H]imipramine from human platelet recognition sites.

7. Imipramine binding site. Temperature dependence of the binding of 3H-labeled imipramine and 3H-labeled paroxetine to human platelet membrane.

8. High affinity binding of [3H]paroxetine and [3H]imipramine to human platelet membranes.

9. Serotonin uptake in blood platelets of psychiatric patients.

10. Platelet 3H-imipramine binding in psychogenic pain patients.

1. Platelet serotonin uptake sites increased in drinkers of ayahuasca.