Literature DB >> 25292339

Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities.

Chang-qing Zhao1, Yang Zhou1, Jian Ping2, Lie-ming Xu3.   

Abstract

Traditional Chinese medicine (TCM) is commonly used in treating liver diseases worldwide, especially in China. The advantages of using TCM for treatment of liver diseases include: protecting hepatocytes, inhibiting hepatic inflammation and antifibrosis in the liver. In this article, we introduce TCM herbal preparations from the Chinese materia medica (such as Fuzheng Huayu) that are typically used for the treatment of liver diseases. Literature surrounding the mechanisms of TCM therapy for treatment of liver diseases is presented and discussed. We propose that side effects of herbal compounds are often under-appreciated, and that more care should be taken in the prescription of potentially hepatotoxic medicines. Further, to deepen the understanding of TCM mechanisms, new techniques and methodologies must be developed. Future studies will lead to the enhancement of clinical outcomes of TCM. As complementary and alternative therapies, TCMs will play an expanding role in the future of liver disease treatment.

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Year:  2014        PMID: 25292339      PMCID: PMC7128864          DOI: 10.1016/S2095-4964(14)60039-X

Source DB:  PubMed          Journal:  J Integr Med


  51 in total

1.  Effects of Fuzhenghuayu decoction on collagen synthesis of cultured hepatic stellate cells, hepatocytes and fibroblasts in rats.

Authors:  Cheng Liu; Ping Liu; Cheng-Hai Liu; Xiu-Qing Zhu; Guang Ji
Journal:  World J Gastroenterol       Date:  1998-12       Impact factor: 5.742

Review 2.  Beneficial effects of traditional Chinese medicine on the treatment of osteoporosis on ovariectomised rat models.

Authors:  Pamela Rufus; Norazlina Mohamed; Ahmad Nazrun Shuid
Journal:  Curr Drug Targets       Date:  2013-12       Impact factor: 3.465

Review 3.  Reversal of hepatic fibrosis -- fact or fantasy?

Authors:  Scott L Friedman; Meena B Bansal
Journal:  Hepatology       Date:  2006-02       Impact factor: 17.425

4.  Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: a multicenter double-blinded randomized controlled trial.

Authors:  Yong-jun Wang; Li-qun He; Wei Sun; Ying Lu; Xiao-qin Wang; Pei-qing Zhang; Lian-bo Wei; Shi-li Cao; Ni-zhi Yang; Hong-zhen Ma; Jing Gao; Ping Li; Xiao-juan Tao; Fa-Huan Yuan; Jing Li; Chen Yao; Xusheng Liu
Journal:  J Ethnopharmacol       Date:  2011-12-13       Impact factor: 4.360

5.  Clinical effect of Jiutengzhuyu tablets on promoting blood circulation in women with oviducal obstruction.

Authors:  Baozhen Pang; Qingyang Pang; Huiqing Pang; Guohong Song
Journal:  J Tradit Chin Med       Date:  2012-12       Impact factor: 0.848

6.  Modified Da-Cheng-Qi Decoction reduces intra-abdominal hypertension in severe acute pancreatitis: a pilot study.

Authors:  Mei-Hua Wan; Juan Li; Wei Huang; Rajarshi Mukherjee; Han-Lin Gong; Qing Xia; Lin Zhu; Gui-Lan Cheng; Wen-Fu Tang
Journal:  Chin Med J (Engl)       Date:  2012-06       Impact factor: 2.628

7.  Therapeutic potential of targeting the renin angiotensin system in portal hypertension.

Authors:  Chandana B Herath; Josephine A Grace; Peter W Angus
Journal:  World J Gastrointest Pathophysiol       Date:  2013-02-15

8.  The anti-asthma herbal medicine ASHMI acutely inhibits airway smooth muscle contraction via prostaglandin E2 activation of EP2/EP4 receptors.

Authors:  Kamal Srivastava; Hugh A Sampson; Charles W Emala; Xiu-Min Li
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2013-10-25       Impact factor: 5.464

9.  Trial of Chinese medicine Wu-Ling-San for acute low-tone hearing loss.

Authors:  Kazunari Okada; Shin-ichi Ishimoto; Yoko Fujimaki; Tatsuya Yamasoba
Journal:  ORL J Otorhinolaryngol Relat Spec       Date:  2012-05-12       Impact factor: 1.538

10.  Prevention of allergic airway hyperresponsiveness and remodeling in mice by Astragaliradix antiasthmatic decoction.

Authors:  Su Xu; Bao-Ping Tian; Lan-Hong Zhang; Wen Hua; Li-Xia Xia; Zhi-Hua Chen; Wen Li; Hua-Hao Shen
Journal:  BMC Complement Altern Med       Date:  2013-12-25       Impact factor: 3.659

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  26 in total

1.  Yu Jin Pulvis inhibits carbon tetrachloride-induced liver fibrosis by blocking the MAPK and PI3K/Akt signaling pathways.

Authors:  Wei Wu; Haiyu Piao; Fushun Wu; Yong Han; Dongzhu An; Yanling Wu; Zhenhua Lin; Yingshi Piao; Jingchun Jin
Journal:  Am J Transl Res       Date:  2019-09-15       Impact factor: 4.060

Review 2.  Critical review of resveratrol in xenobiotic-induced hepatotoxicity.

Authors:  Mitchell R McGill; Kuo Du; James L Weemhoff; Hartmut Jaeschke
Journal:  Food Chem Toxicol       Date:  2015-11-10       Impact factor: 6.023

3.  Hepatoprotective effect of Trigonella foenum graecum against ethanol-induced cell death in human liver cells (HepG2 and Huh7).

Authors:  Nida Nayyar Farshori
Journal:  Mol Biol Rep       Date:  2022-01-22       Impact factor: 2.316

4.  Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression.

Authors:  Yueh-Chiao Yeh; Tsun-Jui Liu; Hui-Chin Lai
Journal:  Evid Based Complement Alternat Med       Date:  2015-02-09       Impact factor: 2.629

5.  Gene Expression Profiling and Pathway Network Analysis Predicts a Novel Antitumor Function for a Botanical-Derived Drug, PG2.

Authors:  Yu-Lun Kuo; Chun-Houh Chen; Tsung-Hsien Chuang; Wei-Kai Hua; Wey-Jinq Lin; Wei-Hsiang Hsu; Peter Mu-Hsin Chang; Shih-Lan Hsu; Tse-Hung Huang; Cheng-Yan Kao; Chi-Ying F Huang
Journal:  Evid Based Complement Alternat Med       Date:  2015-04-20       Impact factor: 2.629

Review 6.  Portulaca oleracea L.: a review of phytochemistry and pharmacological effects.

Authors:  Yan-Xi Zhou; Hai-Liang Xin; Khalid Rahman; Su-Juan Wang; Cheng Peng; Hong Zhang
Journal:  Biomed Res Int       Date:  2015-01-26       Impact factor: 3.411

7.  Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.

Authors:  Chao Zhang; Xuejing Jia; Jiaolin Bao; Shenghui Chen; Kai Wang; Yulin Zhang; Peng Li; Jian-Bo Wan; Huanxing Su; Yitao Wang; Zhinan Mei; Chengwei He
Journal:  BMC Complement Altern Med       Date:  2016-02-09       Impact factor: 3.659

8.  Schisandra Lignan Extract Protects against Carbon Tetrachloride-Induced Liver Injury in Mice by Inhibiting Oxidative Stress and Regulating the NF-κB and JNK Signaling Pathways.

Authors:  Qingshan Chen; Qi Zhan; Ying Li; Sen Sun; Liang Zhao; Hai Zhang; Guoqing Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2017-01-26       Impact factor: 2.629

Review 9.  Role of gut microbiota in identification of novel TCM-derived active metabolites.

Authors:  Tzu-Lung Lin; Chia-Chen Lu; Wei-Fan Lai; Ting-Shu Wu; Jang-Jih Lu; Young-Mao Chen; Chi-Meng Tzeng; Hong-Tao Liu; Hong Wei; Hsin-Chih Lai
Journal:  Protein Cell       Date:  2020-09-15       Impact factor: 14.870

10.  A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice.

Authors:  Zhu-Sheng Chu; Zhi-Ling Yu; Si-Yuan Pan; Zhan-Hong Jia; Xiao-Yan Wang; Yi Zhang; Pei-Li Zhu; Xiu-Juan Wang; Kam-Ming Ko
Journal:  Lipids Health Dis       Date:  2015-08-25       Impact factor: 3.876

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