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Literature DB >> 25291641

Mitotic kinesins: a reason to delve into kinesin-12.

Abstract

The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.

Entities: Disease

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Year: 2014 PMID： 25291641 DOI： 10.1016/j.cub.2014.09.011

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

7 in total

1. Dual localized kinesin-12 POK2 plays multiple roles during cell division and interacts with MAP65-3.

Authors: Arvid Herrmann; Pantelis Livanos; Elisabeth Lipka; Astrid Gadeyne; Marie-Theres Hauser; Daniël Van Damme; Sabine Müller
Journal: EMBO Rep Date: 2018-07-12 Impact factor: 8.807

2. Microtubules: Evolving roles and critical cellular interactions.

Authors: Caitlin M Logan; A Sue Menko
Journal: Exp Biol Med (Maywood) Date: 2019-08-06

3. Functional role for stable microtubules in lens fiber cell elongation.

Authors: Caitlin M Logan; Caitlin J Bowen; A Sue Menko
Journal: Exp Cell Res Date: 2017-12-15 Impact factor: 3.905

4. Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles.

Authors: Hauke Drechsler; Andrew D McAinsh
Journal: Proc Natl Acad Sci U S A Date: 2016-03-11 Impact factor: 11.205

Mitotic kinesins: a reason to delve into kinesin-12.

1. Dual localized kinesin-12 POK2 plays multiple roles during cell division and interacts with MAP65-3.

2. Microtubules: Evolving roles and critical cellular interactions.

3. Functional role for stable microtubules in lens fiber cell elongation.

4. Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles.

5. KINESIN-12E regulates metaphase spindle flux and helps control spindle size in Arabidopsis.

6. Profilin choreographs actin and microtubules in cells and cancer.

Review 7. Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy.