From parasites to allergy: a second receptor for IgE.

Human allergic responses are triggered when mast cells bind IgE antibodies. IgE production is also a regular feature of helminth infection and parasites can be killed by inflammatory cells such as macrophages, eosinophils and platelets sensitized by reaginic antibody. The IgE receptor they use has been identified only recently. Here André Capron and his colleagues discuss how it differs from the IgE receptor present on mast cells.