Literature DB >> 25291330

Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis.

M Rodriguez1, L R Pease, C S David.   

Abstract

The causes of primary demyelination in diseases such as multiple sclerosis are still unknown, but it is possible that immune attack triggered by virus infection may be responsible. Theiler's murine encephalitis is a popular animal model of demyelinating diseases, and in this article Moses Rodriguez and his colleagues describe a hypothetical scheme to explain differential susceptibility of inbred strains to infection. They propose a mechanism by which specific demyelination is produced when immune cells interact with viral antigen and major histocompatibility complex (MHC) antigens.
Copyright © 1986. Published by Elsevier B.V.

Entities:  

Year:  1986        PMID： 25291330     DOI： 10.1016/0167-5699(86)90025-3

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  14 in total

1.  Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.

Authors:  A J Johnson; M K Njenga; M J Hansen; S T Kuhns; L Chen; M Rodriguez; L R Pease
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

Review 2.  Theiler's murine encephalomyelitis virus as an experimental model system to study the mechanism of blood-brain barrier disruption.

Authors:  Holly L Johnson; Fang Jin; Istvan Pirko; Aaron J Johnson
Journal:  J Neurovirol       Date:  2013-07-16       Impact factor: 2.643

Review 3.  T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.

Authors:  F T Rotteveel; C J Lucas
Journal:  Immunol Res       Date:  1990       Impact factor: 2.829

Review 4.  Immunology of Theiler's murine encephalomyelitis virus infection.

Authors:  E L Oleszak; J Kuzmak; R A Good; C D Platsoucas
Journal:  Immunol Res       Date:  1995       Impact factor: 2.829

5.  DNA vaccination against Theiler's murine encephalomyelitis virus leads to alterations in demyelinating disease.

Authors:  N D Tolley; I Tsunoda; R S Fujinami
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

6.  CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.

Authors:  P D Murray; K D Pavelko; J Leibowitz; X Lin; M Rodriguez
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

Review 7.  Multiple sclerosis: basic concepts and hypothesis.

Authors:  M Rodriguez
Journal:  Mayo Clin Proc       Date:  1989-05       Impact factor: 7.616

8.  Virus-specific and autoreactive T cell lines isolated from cerebrospinal fluid of a patient with chronic rubella panencephalitis.

Authors:  R Martin; P Marquardt; S O'Shea; M Borkenstein; H W Kreth
Journal:  J Neuroimmunol       Date:  1989-06       Impact factor: 3.478

9.  Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption.

Authors:  Holly L Johnson; Lisa M Hanson; Yi Chen; Allan J Bieber; Russell J Buono; Thomas N Ferraro; Istvan Pirko; Aaron J Johnson
Journal:  BMC Genomics       Date:  2013-10-03       Impact factor: 3.969

Review 10.  Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison.

Authors:  M C Dal Canto; R W Melvold; B S Kim; S D Miller
Journal:  Microsc Res Tech       Date:  1995-10-15       Impact factor: 2.769
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