Literature DB >> 25291281

The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation.

D D Ma1, T Sylwestrowicz, G Janossy, A V Hoffbrand.   

Abstract

Most cortical thymocytes die within the thymus. It is proposed here that lethally high intracellular levels of deoxynucleosides are the cause of death. Developing thymocytes appropriately equipped for self-recognition are protected because contact with stromal cells prevents the lethal accumulation of deoxynucleosides.
Copyright © 1983. Published by Elsevier B.V.

Entities:  

Year:  1983        PMID： 25291281     DOI： 10.1016/0167-5699(83)90120-2

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  4 in total

1.  Reduction of peritoneal adhesions by sustained and local administration of epidermal growth factor.

Authors:  S Uguralp; M Akin; A Bay Karabulut; B Harma; Aysel Kiziltay; T R Kiran; N Hasirci
Journal:  Pediatr Surg Int       Date:  2007-11-06       Impact factor: 1.827

2.  Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse.

Authors:  F F Snyder; J P Jenuth; E R Mably; R K Mangat
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

3.  Patterns of adenosine deaminase, ecto-5'-nucleotidase, poly(A)polymerase and surface light chain expression in chronic lymphocytic leukemias.

Authors:  T Trangas; N Courtis; A Gounaris; S Perez; D Kokkinopoulos; G A Pangalis; C M Tsiapalis
Journal:  Blut       Date:  1989-04

Review 4.  Enzymes of purine metabolism in lymphoid neoplasms, clinical relevance for treatment with enzyme inhibitors.

Authors:  A D Ho; K Ganeshaguru
Journal:  Klin Wochenschr       Date:  1988-06-01
  4 in total

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