Literature DB >> 2529127

Human complement factor H: an additional gene product of 43 kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement.

R Misasi1, H P Huemer, W Schwaeble, E Sölder, C Larcher, M P Dierich.   

Abstract

In addition to the 150-kDa factor H protein, we have previously described a 43-kDa factor H molecule in human plasma, which probably represents a translational product of the additional 1.8-kb mRNA for factor H. This factor H was isolated from human plasma by means of immunoaffinity chromatography and high-performance liquid chromatography. When tested for its functional activity, this purified 43-kDa H protein was shown to act as cofactor for factor I- mediated cleavage of fluid-phase C3b to iC3b.

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Year:  1989        PMID： 2529127     DOI： 10.1002/eji.1830190936

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  19 in total

1.  Polymorphism and deficiency of human factor H-related proteins p39 and p37.

Authors:  E Feifel; W M Prodinger; M Mölgg; W Schwaeble; D Schönitzer; V Koistinen; R Misasi; M P Dierich
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

2.  Relapsing fever spirochetes Borrelia recurrentis and B. duttonii acquire complement regulators C4b-binding protein and factor H.

Authors:  T Meri; S J Cutler; A M Blom; S Meri; T S Jokiranta
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

3.  The human complement regulatory factor-H-like protein 1, which represents a truncated form of factor H, displays cell-attachment activity.

Authors:  J Hellwage; S Kühn; P F Zipfel
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

Review 4.  The properdin pathway: an "alternative activation pathway" or a "critical amplification loop" for C3 and C5 activation?

Authors:  Richard A Harrison
Journal:  Semin Immunopathol       Date:  2017-11-22       Impact factor: 9.623

5.  Protein H, an antiphagocytic surface protein in Streptococcus pyogenes.

Authors:  B M Kihlberg; M Collin; A Olsén; L Björck
Journal:  Infect Immun       Date:  1999-04       Impact factor: 3.441

6.  Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5.

Authors:  Judith Behnsen; Franziska Lessing; Susann Schindler; Dirk Wartenberg; Ilse D Jacobsen; Marcel Thoen; Peter F Zipfel; Axel A Brakhage
Journal:  Infect Immun       Date:  2010-05-24       Impact factor: 3.441

7.  Generation of multiple fluid-phase C3b:plasma protein complexes during complement activation: possible implications in C3 glomerulopathies.

Authors:  Mahalakshmi Ramadass; Berhane Ghebrehiwet; Richard J Smith; Richard R Kew
Journal:  J Immunol       Date:  2013-12-23       Impact factor: 5.422

8.  The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system.

Authors:  Judith Behnsen; Andrea Hartmann; Jeannette Schmaler; Alexander Gehrke; Axel A Brakhage; Peter F Zipfel
Journal:  Infect Immun       Date:  2007-11-26       Impact factor: 3.441

9.  Determination of soluble CD21 as a parameter of B cell activation.

Authors:  H P Huemer; C Larcher; W M Prodinger; A L Petzer; M Mitterer; N Falser
Journal:  Clin Exp Immunol       Date:  1993-08       Impact factor: 4.330

10.  The yeast Candida albicans binds complement regulators factor H and FHL-1.

Authors:  T Meri; A Hartmann; D Lenk; R Eck; R Würzner; J Hellwage; S Meri; P F Zipfel
Journal:  Infect Immun       Date:  2002-09       Impact factor: 3.441
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