Regulation of delayed-type hypersensitivity to pathogens and alloantigens.

Recent studies reinforce the notion that delayed-type hypersensitivity plays a key role in the host defence against microbial and intracellular parasitic infection, and in the rejection of skin allografts. F. Y. Liew reviews these studies and discusses the observation that this T-cell mediated immunity is profoundly regulated by antigen-specific suppressor T cells, some of which are restricted by products of the I-J subregion of the MHC.