Literature DB >> 25290548

Hybrid hybridomas and the production of bi-specific monoclonal antibodies.

C Milstein1, A C Cuello.   

Abstract

Cell fusion techniques can now be used to generate antibodies with two different specificities. Here Cesar Milstein and A. C. Cuello discuss the theoretical basis of the method they have devised and its first applications in histochemistry and immunoassay.
Copyright © 1984. Published by Elsevier B.V.

Year:  1984        PMID： 25290548     DOI： 10.1016/0167-5699(84)90155-5

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  14 in total

1.  Production of a bi-specific monoclonal antibody recognizing mouse kappa light chains and horseradish peroxidase. Applications in immunoassays.

Authors:  R L Kenigsberg; A C Cuello
Journal:  Histochemistry       Date:  1990

Review 2.  Antibody mediated targeting of radioisotopes, drugs and toxins in diagnosis and treatment.

Authors:  C H Ford; V J Richardson; V S Reddy
Journal:  Indian J Pediatr       Date:  1990 Jan-Feb       Impact factor: 1.967

3.  Development of a bispecific monoclonal antibody against a gallium-67 chelate and the human melanoma-associated antigen p97 for potential use in pretargeted immunoscintigraphy.

Authors:  C Somasundaram; S Matzku; J Schuhmacher; M Zöller
Journal:  Cancer Immunol Immunother       Date:  1993-05       Impact factor: 6.968

4.  Antigen forks: bispecific reagents that inhibit cell growth by binding selected pairs of tumor antigens.

Authors:  D B Ring; S T Hsieh-Ma; T Shi; J Reeder
Journal:  Cancer Immunol Immunother       Date:  1994-07       Impact factor: 6.968

5.  Suppression of well-established tumour xenografts by a hybrid-hybrid monoclonal antibody and vinblastine.

Authors:  W Smith; V A Gore; D R Brandon; D N Lynch; S A Cranstone; J R Corvalan
Journal:  Cancer Immunol Immunother       Date:  1990       Impact factor: 6.968

6.  The production of a "universal developer" for the immunological detection of human IgG and its application in immunodiagnostics.

Authors:  F M Semenenko; R L Kenigsberg; A C Cuello
Journal:  Histochemistry       Date:  1988

7.  Effect of a bifunctional monoclonal antibody directed against a tumor marker and doxorubicin on the growth of epidermoid vulvar carcinoma grafted in athymic mice.

Authors:  D Morelli; S Ménard; B Pozzi; A Balsari; M I Colnaghi
Journal:  Cell Biophys       Date:  1994

8.  Development of a mouse antiperoxidase secreting hybridoma for use in the production of a mouse PAP complex for immunocytochemistry and as a parent cell line in the development of hybrid hybridomas.

Authors:  F M Semenenko; S Bramwell; E Sidebottom; A C Cuello
Journal:  Histochemistry       Date:  1985

9.  Local antitumour treatment in carcinoma patients with bispecific-monoclonal-antibody-redirected T cells.

Authors:  B J Kroesen; A ter Haar; H Spakman; P Willemse; D T Sleijfer; E G de Vries; N H Mulder; H H Berendsen; P C Limburg; T H The
Journal:  Cancer Immunol Immunother       Date:  1993-11       Impact factor: 6.968

10.  A human hybrid hybridoma producing a bispecific monoclonal antibody that can target tumor cells for attack by Pseudomonas aeruginosa exotoxin A.

Authors:  S Honda; Y Ichimori; S Iwasa
Journal:  Cytotechnology       Date:  1990-07       Impact factor: 2.040
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