| Literature DB >> 25290234 |
Erwan Pernet1, Laurent Guillemot2, Pierre-Régis Burgel3, Clémence Martin3, Gérard Lambeau4, Isabelle Sermet-Gaudelus5, Dorota Sands6, Dominique Leduc2, Philippe C Morand7, Louise Jeammet4, Michel Chignard2, Yongzheng Wu2, Lhousseine Touqui2.
Abstract
Young cystic fibrosis (CF) patients' airways are mainly colonized by Staphylococcus aureus, while Pseudomonas aeruginosa predominates in adults. However, the mechanisms behind this infection switch are unclear. Here, we show that levels of type-IIA-secreted phospholipase A2 (sPLA2-IIA, a host enzyme with bactericidal activity) increase in expectorations of CF patients in an age-dependent manner. These levels are sufficient to kill S. aureus, with marginal effects on P. aeruginosa strains. P. aeruginosa laboratory strains and isolates from CF patients induce sPLA2-IIA expression in bronchial epithelial cells from CF patients (these cells are a major source of the enzyme). In an animal model of lung infection, P. aeruginosa induces sPLA2-IIA production that favours S. aureus killing. We suggest that sPLA2-IIA induction by P. aeruginosa contributes to S. aureus eradication in CF airways. Our results indicate that a bacterium can eradicate another bacterium by manipulating the host immunity.Entities:
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Year: 2014 PMID： 25290234 DOI： 10.1038/ncomms6105
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919