| Literature DB >> 2529020 |
Z Han1, B L Kuyatt, K A Kochman, E B DeSouza, G S Roth.
Abstract
Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss during aging was 19%, and also varied considerably within the different striatal regions. Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.Entities:
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Year: 1989 PMID： 2529020 DOI： 10.1016/0006-8993(89)91108-6
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252