Literature DB >> 25288112

Liquid-liquid phase separation in biology.

Anthony A Hyman1, Christoph A Weber, Frank Jülicher.   

Abstract

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary to understand the consequences of liquid-like states for biological functions.

Keywords:  P granules; biological liquids; chemical potential; origin of life; phase separation

Mesh：

Substances：

Year:  2014        PMID： 25288112     DOI： 10.1146/annurev-cellbio-100913-013325

Source DB:  PubMed          Journal:  Annu Rev Cell Dev Biol        ISSN： 1081-0706            Impact factor:   13.827


  711 in total

1.  Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation.

Authors:  Roubina Tatavosian; Samantha Kent; Kyle Brown; Tingting Yao; Huy Nguyen Duc; Thao Ngoc Huynh; Chao Yu Zhen; Brian Ma; Haobin Wang; Xiaojun Ren
Journal:  J Biol Chem       Date:  2018-12-04       Impact factor: 5.157

2.  Organizing the oocyte: RNA localization meets phase separation.

Authors:  Sarah E Cabral; Kimberly L Mowry
Journal:  Curr Top Dev Biol       Date:  2020-03-09       Impact factor: 4.897

3.  Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation in Pseudomonas aeruginosa.

Authors:  Lisa R Racki; Elitza I Tocheva; Michael G Dieterle; Meaghan C Sullivan; Grant J Jensen; Dianne K Newman
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-06       Impact factor: 11.205

Review 4.  More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change.

Authors:  Anupam K Chakravarty; Daniel F Jarosz
Journal:  J Mol Biol       Date:  2018-07-19       Impact factor: 5.469

5.  Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.

Authors:  Erik C Gunther; Levi M Smith; Mikhail A Kostylev; Timothy O Cox; Adam C Kaufman; Suho Lee; Ewa Folta-Stogniew; George D Maynard; Ji Won Um; Massimiliano Stagi; Jacqueline K Heiss; Austin Stoner; Geoff P Noble; Hideyuki Takahashi; Laura T Haas; John S Schneekloth; Janie Merkel; Christopher Teran; Zahra K Naderi; Surachai Supattapone; Stephen M Strittmatter
Journal:  Cell Rep       Date:  2019-01-02       Impact factor: 9.423

6.  Phase transition of spindle-associated protein regulate spindle apparatus assembly.

Authors:  Hao Jiang; Shusheng Wang; Yuejia Huang; Xiaonan He; Honggang Cui; Xueliang Zhu; Yixian Zheng
Journal:  Cell       Date:  2015-09-17       Impact factor: 41.582

7.  Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events.

Authors:  Jenny J Y Lin; Shalini T Low-Nam; Katherine N Alfieri; Darren B McAffee; Nicole C Fay; Jay T Groves
Journal:  Sci Signal       Date:  2019-01-15       Impact factor: 8.192

Review 8.  Single-molecule fluorescence studies of intrinsically disordered proteins and liquid phase separation.

Authors:  Irem Nasir; Paulo L Onuchic; Sergio R Labra; Ashok A Deniz
Journal:  Biochim Biophys Acta Proteins Proteom       Date:  2019-05-02       Impact factor: 3.036

9.  Structured States of Disordered Proteins from Genomic Sequences.

Authors:  Agnes Toth-Petroczy; Perry Palmedo; John Ingraham; Thomas A Hopf; Bonnie Berger; Chris Sander; Debora S Marks
Journal:  Cell       Date:  2016-09-22       Impact factor: 41.582

Review 10.  The Role of RNA in Biological Phase Separations.

Authors:  Marta M Fay; Paul J Anderson
Journal:  J Mol Biol       Date:  2018-05-10       Impact factor: 5.469
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