Literature DB >> 25288093

Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits Candida albicans and Staphylococcus aureus biofilm formation in vivo.

Kaat De Cremer1, Nicolas Delattin2, Katrijn De Brucker2, Annelies Peeters2, Soña Kucharíková3, Evelien Gerits2, Natalie Verstraeten2, Jan Michiels2, Patrick Van Dijck3, Bruno P A Cammue4, Karin Thevissen2.   

Abstract

We here report on the in vitro activity of toremifene to inhibit biofilm formation of different fungal and bacterial pathogens, including Candida albicans, Candida glabrata, Candida dubliniensis, Candida krusei, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. We validated the in vivo efficacy of orally administered toremifene against C. albicans and S. aureus biofilm formation in a rat subcutaneous catheter model. Combined, our results demonstrate the potential of toremifene as a broad-spectrum oral antibiofilm compound.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25288093      PMCID： PMC4249581          DOI： 10.1128/AAC.03869-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  48 in total

Review 1.  Bacterial biofilms: a common cause of persistent infections.

Authors:  J W Costerton; P S Stewart; E P Greenberg
Journal:  Science       Date:  1999-05-21       Impact factor: 47.728

2.  Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.

Authors:  Ainslie B Parsons; Andres Lopez; Inmar E Givoni; David E Williams; Christopher A Gray; Justin Porter; Gordon Chua; Richelle Sopko; Renee L Brost; Cheuk-Hei Ho; Jiyi Wang; Troy Ketela; Charles Brenner; Julie A Brill; G Esteban Fernandez; Todd C Lorenz; Gregory S Payne; Satoru Ishihara; Yoshikazu Ohya; Brenda Andrews; Timothy R Hughes; Brendan J Frey; Todd R Graham; Raymond J Andersen; Charles Boone
Journal:  Cell       Date:  2006-08-11       Impact factor: 41.582

Review 3.  Strength in numbers: antifungal strategies against fungal biofilms.

Authors:  Gordon Ramage; Shaun N Robertson; Craig Williams
Journal:  Int J Antimicrob Agents       Date:  2013-11-25       Impact factor: 5.283

4.  ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.

Authors:  O A Cornely; M Bassetti; T Calandra; J Garbino; B J Kullberg; O Lortholary; W Meersseman; M Akova; M C Arendrup; S Arikan-Akdagli; J Bille; E Castagnola; M Cuenca-Estrella; J P Donnelly; A H Groll; R Herbrecht; W W Hope; H E Jensen; C Lass-Flörl; G Petrikkos; M D Richardson; E Roilides; P E Verweij; C Viscoli; A J Ullmann
Journal:  Clin Microbiol Infect       Date:  2012-12       Impact factor: 8.067

5.  High-dose toremifene vs tamoxifen in postmenopausal advanced breast cancer.

Authors:  M Gershanovich; D F Hayes; J Ellmén; J Vuorinen
Journal:  Oncology (Williston Park)       Date:  1997-05       Impact factor: 2.990

6.  Antiestrogenic and antitumor properties of the new triphenylethylene derivative toremifene in the rat.

Authors:  E di Salle; T Zaccheo; G Ornati
Journal:  J Steroid Biochem       Date:  1990-06-22       Impact factor: 4.292

7.  Candida albicans biofilm formation in a new in vivo rat model.

Authors:  Markéta Řičicová; Soňa Kucharíková; Hélène Tournu; Jelle Hendrix; Helena Bujdáková; Johan Van Eldere; Katrien Lagrou; Patrick Van Dijck
Journal:  Microbiology       Date:  2009-12-03       Impact factor: 2.777

8.  Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals.

Authors:  D J Sullivan; T J Westerneng; K A Haynes; D E Bennett; D C Coleman
Journal:  Microbiology       Date:  1995-07       Impact factor: 2.777

9.  Genotoxicity studies with the antiestrogen toremifene.

Authors:  G M Williams; P M Ross; A M Jeffrey; S Karlsson
Journal:  Drug Chem Toxicol       Date:  1998-11       Impact factor: 3.356

10.  FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.

Authors:  Lisa M Johansen; Jennifer M Brannan; Sue E Delos; Charles J Shoemaker; Andrea Stossel; Calli Lear; Benjamin G Hoffstrom; Lisa Evans Dewald; Kathryn L Schornberg; Corinne Scully; Joseph Lehár; Lisa E Hensley; Judith M White; Gene G Olinger
Journal:  Sci Transl Med       Date:  2013-06-19       Impact factor: 17.956
View more
  7 in total

1.  Innovative Physical Approaches for Onychomycosis: Peeling, Lasers and Beyond.

Authors:  Sidharth Sonthalia; Mohamad Goldust
Journal:  Skin Appendage Disord       Date:  2019-03-01

2.  Repurposing Toremifene for Treatment of Oral Bacterial Infections.

Authors:  Evelien Gerits; Valerie Defraine; Katleen Vandamme; Kaat De Cremer; Katrijn De Brucker; Karin Thevissen; Bruno P A Cammue; Serge Beullens; Maarten Fauvart; Natalie Verstraeten; Jan Michiels
Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

Review 3.  Intestinal Infection of Candida albicans: Preventing the Formation of Biofilm by C. albicans and Protecting the Intestinal Epithelial Barrier.

Authors:  Ziyao Peng; Jianguo Tang
Journal:  Front Microbiol       Date:  2022-02-02       Impact factor: 5.640

4.  Small Molecules Produced by Commensal Staphylococcus epidermidis Disrupt Formation of Biofilms by Staphylococcus aureus.

Authors:  Thaís Glatthardt; Juliana Curityba de Mello Campos; Raiane Cardoso Chamon; Thiago Freitas de Sá Coimbra; Giulia de Almeida Rocha; Marília Alves Figueira de Melo; Thiago Estevam Parente; Leandro Araujo Lobo; Luis Caetano Martha Antunes; Kátia Regina Netto Dos Santos; Rosana Barreto Rocha Ferreira
Journal:  Appl Environ Microbiol       Date:  2020-02-18       Impact factor: 4.792

Review 5.  Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Authors:  Patrick Van Dijck; Jelmer Sjollema; Bruno P Cammue; Katrien Lagrou; Judith Berman; Christophe d'Enfert; David R Andes; Maiken C Arendrup; Axel A Brakhage; Richard Calderone; Emilia Cantón; Tom Coenye; Paul Cos; Leah E Cowen; Mira Edgerton; Ana Espinel-Ingroff; Scott G Filler; Mahmoud Ghannoum; Neil A R Gow; Hubertus Haas; Mary Ann Jabra-Rizk; Elizabeth M Johnson; Shawn R Lockhart; Jose L Lopez-Ribot; Johan Maertens; Carol A Munro; Jeniel E Nett; Clarissa J Nobile; Michael A Pfaller; Gordon Ramage; Dominique Sanglard; Maurizio Sanguinetti; Isabel Spriet; Paul E Verweij; Adilia Warris; Joost Wauters; Michael R Yeaman; Sebastian A J Zaat; Karin Thevissen
Journal:  Microb Cell       Date:  2018-06-14

Review 6.  Bioactive Peptides Against Fungal Biofilms.

Authors:  Karen G N Oshiro; Gisele Rodrigues; Bruna Estéfani D Monges; Marlon Henrique Cardoso; Octávio Luiz Franco
Journal:  Front Microbiol       Date:  2019-10-04       Impact factor: 5.640

7.  Repurposing of the Tamoxifen Metabolites to Treat Methicillin-Resistant Staphylococcus epidermidis and Vancomycin-Resistant Enterococcus faecalis Infections.

Authors:  Andrea Miró-Canturri; Andrea Vila-Domínguez; Marta Caretero-Ledesma; Rafael Ayerbe-Algaba; Jerónimo Pachón; Manuel Enrique Jiménez-Mejías; Younes Smani
Journal:  Microbiol Spectr       Date:  2021-10-20
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.