BACKGROUND: Previous studies have offered conflicting results regarding an association between perioperative epidural analgesia and disease-free survival (DFS) following optimal primary cytoreductive surgery for stage III epithelial ovarian cancer. A possible separate role for inhalational anesthetics has not been assessed. METHODS: We conducted a historical cohort study of all women undergoing optimal primary cytoreduction (<1 cm residual disease) for Stage III epithelial ovarian cancer between January 1, 2007, and December 31, 2011, at Brigham and Women's Hospital. Cohorts were defined by exposure to perioperative epidural analgesia or exposure to specific volatile anesthetics. The primary outcome was DFS. RESULTS: A total of 194 patients met study inclusion criteria. Addition of epidural analgesia was associated with a lower overall rate of ovarian cancer recurrence compared with general anesthesia alone (72 vs. 85 %, p = 0.028). Longer median DFS was associated with more than 48 h of epidural use (14.9 months) compared with fewer than 24 h (10.9 months) or 24-48 h of epidural use (10.0 months; p = 0.025). Use of desflurane was associated with a lower overall rate of ovarian cancer recurrence compared with sevoflurane (63 vs. 84 %, p = 0.01). In multivariate analysis, use of desflurane was independently associated with improved DFS (hazards ratio 0.563; 95% confidence interval 0.33-0.962). CONCLUSIONS: For patients with Stage III ovarian cancer, use of desflurane is associated with improved DFS following primary cytoreductive surgery compared with other volatile anesthetics. If epidural analgesia offers additional benefit, this effect appears limited to patients with more than 48 h of postoperative epidural use.
BACKGROUND: Previous studies have offered conflicting results regarding an association between perioperative epidural analgesia and disease-free survival (DFS) following optimal primary cytoreductive surgery for stage III epithelial ovarian cancer. A possible separate role for inhalational anesthetics has not been assessed. METHODS: We conducted a historical cohort study of all women undergoing optimal primary cytoreduction (<1 cm residual disease) for Stage III epithelial ovarian cancer between January 1, 2007, and December 31, 2011, at Brigham and Women's Hospital. Cohorts were defined by exposure to perioperative epidural analgesia or exposure to specific volatile anesthetics. The primary outcome was DFS. RESULTS: A total of 194 patients met study inclusion criteria. Addition of epidural analgesia was associated with a lower overall rate of ovarian cancer recurrence compared with general anesthesia alone (72 vs. 85 %, p = 0.028). Longer median DFS was associated with more than 48 h of epidural use (14.9 months) compared with fewer than 24 h (10.9 months) or 24-48 h of epidural use (10.0 months; p = 0.025). Use of desflurane was associated with a lower overall rate of ovarian cancer recurrence compared with sevoflurane (63 vs. 84 %, p = 0.01). In multivariate analysis, use of desflurane was independently associated with improved DFS (hazards ratio 0.563; 95% confidence interval 0.33-0.962). CONCLUSIONS: For patients with Stage III ovarian cancer, use of desflurane is associated with improved DFS following primary cytoreductive surgery compared with other volatile anesthetics. If epidural analgesia offers additional benefit, this effect appears limited to patients with more than 48 h of postoperative epidural use.
Authors: Jill H Tseng; Renee A Cowan; Anoushka M Afonso; Qin Zhou; Alexia Iasonos; Narisha Ali; Errika Thompson; Yukio Sonoda; Roisin E O'Cearbhaill; Dennis S Chi; Nadeem R Abu-Rustum; Kara Long Roche Journal: Gynecol Oncol Date: 2018-09-02 Impact factor: 5.482
Authors: Ho Seok Seo; Kyo Young Song; Yoon Ju Jung; Seung Man Park; Hae Myung Jeon; Wook Kim; Hyung Min Chin; Jin-Jo Kim; Sung Keun Kim; Kyung Hwa Chun; Jeong Goo Kim; Jun Hyun Lee; Han Hong Lee; Dong Jin Kim; Han Mo Yoo; Chang Hyun Kim; Eun Young Kim; Cho Hyun Park Journal: World J Surg Date: 2018-10 Impact factor: 3.352
Authors: Juan P Cata; Vinny Singh; Brenda M Lee; John Villarreal; John R Mehran; J Yu; Vijaya Gottumukkala; Hagar Lavon; Shamgar Ben-Eliyahu Journal: J Anaesthesiol Clin Pharmacol Date: 2017 Jul-Sep