T da Silva Alexandre1, Y A de Oliveira Duarte, J L Ferreira Santos, R Wong, M L Lebrão. 1. Tiago da Silva Alexandre, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos/UFSCar, Sala 16, Telefone 55 (16) 3306-6661, Brazil, tsfisioalex@gmail.com, Fax: +1 317 433 6590, Email: wrobleskikr@lilly.com.
Abstract
BACKGROUND: Sarcopenia and dynapenia have been associated with poorer physical performance, disability and death. The aim of this study was to compare the association between sarcopenia and dynapenia with mortality. METHODS: We studied 1,149 Brazilians aged 60 years or older residing in São Paulo. Sarcopenia was defined according to the consensus of the European Working Group on Sarcopenia in Older People (EWGSOP), which includes three components: low muscle mass (LMM) assessed by skeletal muscle mass index ≤ 8.90kg/m2 (men) and ≤ 6.37kg/m2 (women); low muscle strength (LMS) assessed by handgrip strength <30kg (men) and < 20kg (women); and low physical performance (LPP) assessed by walking speed ≤ 0.8m/s. Diagnosis of sarcopenia required presence of LMM plus LMS or LPP. Dynapenia was defined as handgrip strength < 30kg (men) and < 20kg (women). Covariates included socio-demographic and behavioral variables, medical conditions, hospitalization, depressive symptoms, cognition, and disability in activities of daily living or instrumental activities of daily living. The outcome was all-cause mortality over five-year follow-up. RESULTS: During the five-year follow-up, 187 subjects died. The mortality rate for those with or without sarcopenia were 65.9/1,000 person/years and 20.1/1,000 person/years and for dynapenia were 44.3/1,000 person/years and 14.9/1,000 person/years. The adjusted model showed that sarcopenia (HR=1.52, 95%CI: 1.06 - 2.19) and dynapenia (HR=2.04, 95%CI: 1.24 - 3.37) are independent risk factors for death. CONCLUSIONS: The EWGSOP definition of sarcopenia and dynapenia can help to determine risk for mortality and can be used as a screening instrument in public health.
BACKGROUND:Sarcopenia and dynapenia have been associated with poorer physical performance, disability and death. The aim of this study was to compare the association between sarcopenia and dynapenia with mortality. METHODS: We studied 1,149 Brazilians aged 60 years or older residing in São Paulo. Sarcopenia was defined according to the consensus of the European Working Group on Sarcopenia in Older People (EWGSOP), which includes three components: low muscle mass (LMM) assessed by skeletal muscle mass index ≤ 8.90kg/m2 (men) and ≤ 6.37kg/m2 (women); low muscle strength (LMS) assessed by handgrip strength <30kg (men) and < 20kg (women); and low physical performance (LPP) assessed by walking speed ≤ 0.8m/s. Diagnosis of sarcopenia required presence of LMM plus LMS or LPP. Dynapenia was defined as handgrip strength < 30kg (men) and < 20kg (women). Covariates included socio-demographic and behavioral variables, medical conditions, hospitalization, depressive symptoms, cognition, and disability in activities of daily living or instrumental activities of daily living. The outcome was all-cause mortality over five-year follow-up. RESULTS: During the five-year follow-up, 187 subjects died. The mortality rate for those with or without sarcopenia were 65.9/1,000 person/years and 20.1/1,000 person/years and for dynapenia were 44.3/1,000 person/years and 14.9/1,000 person/years. The adjusted model showed that sarcopenia (HR=1.52, 95%CI: 1.06 - 2.19) and dynapenia (HR=2.04, 95%CI: 1.24 - 3.37) are independent risk factors for death. CONCLUSIONS: The EWGSOP definition of sarcopenia and dynapenia can help to determine risk for mortality and can be used as a screening instrument in public health.
Authors: Francesco Landi; Rosa Liperoti; Domenico Fusco; Simona Mastropaolo; Davide Quattrociocchi; Anna Proia; Matteo Tosato; Roberto Bernabei; Graziano Onder Journal: J Am Med Dir Assoc Date: 2012-02 Impact factor: 4.669
Authors: Anne B Newman; Varant Kupelian; Marjolein Visser; Eleanor M Simonsick; Bret H Goodpaster; Stephen B Kritchevsky; Frances A Tylavsky; Susan M Rubin; Tamara B Harris Journal: J Gerontol A Biol Sci Med Sci Date: 2006-01 Impact factor: 6.053
Authors: Francesco Landi; Alfonso J Cruz-Jentoft; Rosa Liperoti; Andrea Russo; Silvia Giovannini; Matteo Tosato; Ettore Capoluongo; Roberto Bernabei; Graziano Onder Journal: Age Ageing Date: 2013-01-15 Impact factor: 10.668
Authors: V E Arango-Lopera; P Arroyo; L M Gutiérrez-Robledo; M U Pérez-Zepeda; M Cesari Journal: J Nutr Health Aging Date: 2013-03 Impact factor: 4.075
Authors: Alfonso J Cruz-Jentoft; Jean Pierre Baeyens; Jürgen M Bauer; Yves Boirie; Tommy Cederholm; Francesco Landi; Finbarr C Martin; Jean-Pierre Michel; Yves Rolland; Stéphane M Schneider; Eva Topinková; Maurits Vandewoude; Mauro Zamboni Journal: Age Ageing Date: 2010-04-13 Impact factor: 10.668
Authors: T da Silva Alexandre; Y A de Oliveira Duarte; J L Ferreira Santos; R Wong; M L Lebrão Journal: J Nutr Health Aging Date: 2014-05 Impact factor: 4.075
Authors: J C Menant; F Weber; J Lo; D L Sturnieks; J C Close; P S Sachdev; H Brodaty; S R Lord Journal: Osteoporos Int Date: 2016-07-09 Impact factor: 4.507
Authors: T da Silva Alexandre; S Scholes; J L Ferreira Santos; Y A de Oliveira Duarte; C de Oliveira Journal: J Nutr Health Aging Date: 2018 Impact factor: 4.075
Authors: K S de Souza Vasconcelos; J M Domingues Dias; A de Carvalho Bastone; R Alvarenga Vieira; A C de Souza Andrade; M Rodrigues Perracini; R Oliveira Guerra; R Corrêa Dias Journal: J Nutr Health Aging Date: 2016-03 Impact factor: 4.075
Authors: S Yadigar; H Yavuzer; S Yavuzer; M Cengiz; M Yürüyen; A Döventaş; D S Erdinçler Journal: J Nutr Health Aging Date: 2016-03 Impact factor: 4.075
Authors: Peggy M Cawthon; Thomas G Travison; Todd M Manini; Sheena Patel; Karol M Pencina; Roger A Fielding; Jay M Magaziner; Anne B Newman; Todd Brown; Douglas P Kiel; Steve R Cummings; Michelle Shardell; Jack M Guralnik; Linda J Woodhouse; Marco Pahor; Ellen Binder; Ralph B D'Agostino; Xue Quian-Li; Eric Orwoll; Francesco Landi; Denise Orwig; Laura Schaap; Nancy K Latham; Vasant Hirani; Timothy Kwok; Suzette L Pereira; Daniel Rooks; Makoto Kashiwa; Moises Torres-Gonzalez; Joseph P Menetski; Rosaly Correa-De-Araujo; Shalender Bhasin Journal: J Gerontol A Biol Sci Med Sci Date: 2020-06-18 Impact factor: 6.053
Authors: Lara Bianchi; Luigi Ferrucci; Antonio Cherubini; Marcello Maggio; Stefania Bandinelli; Elisabetta Savino; Gloria Brombo; Giovanni Zuliani; Jack M Guralnik; Francesco Landi; Stefano Volpato Journal: J Gerontol A Biol Sci Med Sci Date: 2015-09-02 Impact factor: 6.053