Literature DB >> 25285458

A preclinical murine model of hepatic metastases.

Kevin C Soares1, Kelly Foley2, Kelly Olino1, Ashley Leubner2, Skye C Mayo1, Ajay Jain1, Elizabeth Jaffee2, Richard D Schulick3, Kiyoshi Yoshimura4, Barish Edil5, Lei Zheng6.   

Abstract

Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.

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Year:  2014        PMID： 25285458      PMCID： PMC4378377          DOI： 10.3791/51677

Source DB:  PubMed          Journal:  J Vis Exp        ISSN： 1940-087X            Impact factor:   1.355


  12 in total

1.  Effective depletion of regulatory T cells allows the recruitment of mesothelin-specific CD8 T cells to the antitumor immune response against a mesothelin-expressing mouse pancreatic adenocarcinoma.

Authors:  Ihid C Leao; Priya Ganesan; Todd D Armstrong; Elizabeth M Jaffee
Journal:  Clin Transl Sci       Date:  2008-12       Impact factor: 4.689

2.  Blood flow evaluation in high-frequency, 40 MHz imaging: a comparative study of four vector velocity estimation methods.

Authors:  Adrien Marion; Walid Aoudi; Adrian Basarab; Philippe Delachartre; Didier Vray
Journal:  Ultrasonics       Date:  2010-01-25       Impact factor: 2.890

3.  Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes.

Authors:  Kiyoshi Yoshimura; Ajay Jain; Heather E Allen; Lindsay S Laird; Christina Y Chia; Sowmya Ravi; Dirk G Brockstedt; Martin A Giedlin; Keith S Bahjat; Meredith L Leong; Jill E Slansky; David N Cook; Thomas W Dubensky; Drew M Pardoll; Richard D Schulick
Journal:  Cancer Res       Date:  2006-01-15       Impact factor: 12.701

4.  Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.

Authors:  Sunil R Hingorani; Lifu Wang; Asha S Multani; Chelsea Combs; Therese B Deramaudt; Ralph H Hruban; Anil K Rustgi; Sandy Chang; David A Tuveson
Journal:  Cancer Cell       Date:  2005-05       Impact factor: 31.743

5.  Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice.

Authors:  T H Corbett; B J Roberts; W R Leopold; J C Peckham; L J Wilkoff; D P Griswold; F M Schabel
Journal:  Cancer Res       Date:  1984-02       Impact factor: 12.701

Review 6.  Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer.

Authors:  Carolyn E Clark; Gregory L Beatty; Robert H Vonderheide
Journal:  Cancer Lett       Date:  2008-11-14       Impact factor: 8.679

Review 7.  Maximizing mouse cancer models.

Authors:  Kristopher K Frese; David A Tuveson
Journal:  Nat Rev Cancer       Date:  2007-09       Impact factor: 60.716

8.  Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases.

Authors:  Ajay Jain; Jill E Slansky; Laurel C Matey; Heather E Allen; Drew M Pardoll; Richard D Schulick
Journal:  Ann Surg Oncol       Date:  2003-08       Impact factor: 5.344

9.  Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.

Authors:  Lei Zheng; Kelly Foley; Lanqing Huang; Ashley Leubner; Guanglan Mo; Kelly Olino; Barish H Edil; Masamichi Mizuma; Rajni Sharma; Dung T Le; Robert A Anders; Peter B Illei; Jennifer E Van Eyk; Anirban Maitra; Daniel Laheru; Elizabeth M Jaffee
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240

10.  Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases.

Authors:  Kelly Olino; Satoshi Wada; Barish H Edil; Xiaoyu Pan; Kristen Meckel; Walter Weber; Jill Slansky; Koji Tamada; Peter Lauer; Dirk Brockstedt; Drew Pardoll; Richard Schulick; Kiyoshi Yoshimura
Journal:  Ann Surg Oncol       Date:  2011-10-07       Impact factor: 5.344
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  63 in total

1.  STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.

Authors:  Juan Fu; David B Kanne; Meredith Leong; Laura Hix Glickman; Sarah M McWhirter; Edward Lemmens; Ken Mechette; Justin J Leong; Peter Lauer; Weiqun Liu; Kelsey E Sivick; Qi Zeng; Kevin C Soares; Lei Zheng; Daniel A Portnoy; Joshua J Woodward; Drew M Pardoll; Thomas W Dubensky; Young Kim
Journal:  Sci Transl Med       Date:  2015-04-15       Impact factor: 17.956

2.  Hedgehog signaling stimulates Tenascin C to promote invasion of pancreatic ductal adenocarcinoma cells through Annexin A2.

Authors:  Kelly Foley; Stephen Muth; Elizabeth Jaffee; Lei Zheng
Journal:  Cell Adh Migr       Date:  2017-02-06       Impact factor: 3.405

3.  Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones.

Authors:  Go Oshima; Melinda E Stack; Sean C Wightman; Darren Bryan; Elizabeth Poli; Lai Xue; Kinga B Skowron; Abhineet Uppal; Sean P Pitroda; Xiaona Huang; Mitchell C Posner; Samuel Hellman; Ralph R Weichselbaum; Nikolai N Khodarev
Journal:  J Vis Exp       Date:  2016-11-30       Impact factor: 1.355

4.  Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+) ;LSL-Trp53(R172H/+) ;Pdx-1-Cre), Its Variants, and Their Application in Immuno-oncology Drug Discovery.

Authors:  Jae W Lee; Chad A Komar; Fee Bengsch; Kathleen Graham; Gregory L Beatty
Journal:  Curr Protoc Pharmacol       Date:  2016-06-01

5.  Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.

Authors:  Jae-Seok Roe; Chang-Il Hwang; Tim D D Somerville; Joseph P Milazzo; Eun Jung Lee; Brandon Da Silva; Laura Maiorino; Hervé Tiriac; C Megan Young; Koji Miyabayashi; Dea Filippini; Brianna Creighton; Richard A Burkhart; Jonathan M Buscaglia; Edward J Kim; Jean L Grem; Audrey J Lazenby; James A Grunkemeyer; Michael A Hollingsworth; Paul M Grandgenett; Mikala Egeblad; Youngkyu Park; David A Tuveson; Christopher R Vakoc
Journal:  Cell       Date:  2017-07-27       Impact factor: 41.582

6.  Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer.

Authors:  Alex B Blair; Victoria M Kim; Stephen T Muth; May Tun Saung; Nathalie Lokker; Barbara Blouw; Todd D Armstrong; Elizabeth M Jaffee; Takahiro Tsujikawa; Lisa M Coussens; Jin He; Richard A Burkhart; Christopher L Wolfgang; Lei Zheng
Journal:  Clin Cancer Res       Date:  2019-06-11       Impact factor: 12.531

7.  In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish.

Authors:  Xiaodan Qin; Fabrice F J Laroche; Saquib Ahmed M A Peerzade; Andrew Lam; Igor Sokolov; Hui Feng
Journal:  J Vis Exp       Date:  2020-05-08       Impact factor: 1.355

8.  Testing the Vascular Invasive Ability of Cancer Cells in Zebrafish (Danio Rerio).

Authors:  Eric B Berens; Ghada M Sharif; Anton Wellstein; Eric Glasgow
Journal:  J Vis Exp       Date:  2016-11-03       Impact factor: 1.355

9.  A CD40 Agonist and PD-1 Antagonist Antibody Reprogram the Microenvironment of Nonimmunogenic Tumors to Allow T-cell-Mediated Anticancer Activity.

Authors:  Hayley S Ma; Bibhav Poudel; Evanthia Roussos Torres; John-William Sidhom; Tara M Robinson; Brian Christmas; Blake Scott; Kayla Cruz; Skylar Woolman; Valerie Z Wall; Todd Armstrong; Elizabeth M Jaffee
Journal:  Cancer Immunol Res       Date:  2019-01-14       Impact factor: 11.151

10.  Preclinical Imaging Using Single Track Location Shear Wave Elastography: Monitoring the Progression of Murine Pancreatic Tumor Liver Metastasis In Vivo.

Authors:  Rifat Ahmed; Jian Ye; Scott A Gerber; David C Linehan; Marvin M Doyley
Journal:  IEEE Trans Med Imaging       Date:  2020-02-03       Impact factor: 10.048
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