| Literature DB >> 2528505 |
D N Sauder1, F W Orr, S Matic, D Stetsko, K P Parker, R Chizzonite, P L Kilian.
Abstract
Interleukin-1 (IL-1) has been shown to have mitogenic and chemotactic properties for a variety of cell types includes keratinocytes. These studies suggested that keratinocytes possess receptors for IL-1. In this study, the chemotactic properties of IL-1 for keratinocytes were confirmed and IL-1 receptors were demonstrated on keratinocytes using a radio receptor assay. Crosslinking studies with IL-1 alpha identified two major bands of Mr 97 kDa and 133 kDa. Thus, keratinocytes possess high affinity IL-1 receptors and respond to IL-1 by directed migration.Entities:
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Year: 1989 PMID： 2528505 DOI： 10.1016/0165-2478(89)90178-8
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685