| Literature DB >> 25284248 |
Zhichao Jin1, Shaojin Chen, Yuhuang Wang, Pengcheng Zheng, Song Yang, Yonggui Robin Chi.
Abstract
The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the β carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging β-alkyl substituents work effectively.Entities:
Keywords: N-heterocyclic carbenes; anhydrides; asymmetric synthesis; organocatalysis; β-functionalization
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Year: 2014 PMID： 25284248 DOI： 10.1002/anie.201408604
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336