William Qubty1, Deborah L Renaud2. 1. Department of Neurology, Mayo Clinic, Rochester, Minnesota. 2. Department of Neurology, Mayo Clinic, Rochester, Minnesota; Department of Pediatrics, Mayo Clinic, Rochester, Minnesota. Electronic address: renaud.deborah@mayo.edu.
Abstract
BACKGROUND: Iron deficiency is the most common nutritional deficiency in children. It affects 9% of children ages 1-3 years. Iron is essential for effective mitochondrial electron transport and neurotransmitter synthesis. Iron deficiency has been correlated with impaired psychomotor development, pica, attention deficit disorder, periodic limb movements of sleep, and breath-holding spells. Ferritin is the storage form of iron. PATIENT SERIES: We assessed three children referred for developmental concerns. Extensive testing and neuroimaging were all unremarkable except for low iron stores. Dietary histories revealed excessive milk consumption in two of the children. After dietary adjustments and iron supplementation, iron stores normalized. CONCLUSIONS: This cohort demonstrated a dramatic improvement in cognition once iron stores were repleted, suggesting iron studies should be considered as part of initial investigations of patients with cognitive concerns.
BACKGROUND:Iron deficiency is the most common nutritional deficiency in children. It affects 9% of children ages 1-3 years. Iron is essential for effective mitochondrial electron transport and neurotransmitter synthesis. Iron deficiency has been correlated with impaired psychomotor development, pica, attention deficit disorder, periodic limb movements of sleep, and breath-holding spells. Ferritin is the storage form of iron. PATIENT SERIES: We assessed three children referred for developmental concerns. Extensive testing and neuroimaging were all unremarkable except for low iron stores. Dietary histories revealed excessive milk consumption in two of the children. After dietary adjustments and iron supplementation, iron stores normalized. CONCLUSIONS: This cohort demonstrated a dramatic improvement in cognition once iron stores were repleted, suggesting iron studies should be considered as part of initial investigations of patients with cognitive concerns.
Authors: Ana M López-Sobaler; Aránzazu Aparicio; Liliana G González-Rodríguez; Esther Cuadrado-Soto; Josefa Rubio; Victoria Marcos; Rosa Sanchidrián; Sara Santos; Napoleón Pérez-Farinós; Marian Ángeles Dal Re; Carmen Villar; Teresa Robledo; J Javier Castrodeza; Rosa M Ortega Journal: Nutrients Date: 2017-02-13 Impact factor: 5.717
Authors: Rebecca L Cook; Nicholas J O'Dwyer; Helen M Parker; Cheyne E Donges; Hoi Lun Cheng; Katharine S Steinbeck; Eka P Cox; Janet L Franklin; Manohar L Garg; Kieron B Rooney; Helen T O'Connor Journal: Nutrients Date: 2017-11-05 Impact factor: 5.717