Literature DB >> 25283186

Effect of methylprednisolone on mammalian neuronal networks in vitro.

Matthias Wittstock1, Paulus S Rommer, Florian Schiffmann, Konstantin Jügelt, Simone Stüwe, Reiner Benecke, Dietmar Schiffmann, Uwe K Zettl.   

Abstract

Glucocorticosteroids (GCS) are widely used for the treatment of neurological diseases, e.g. multiple sclerosis. High levels of GCS are toxic to the central nervous system and can produce adverse effects. The effect of methylprednisolone (MP) on mammalian neuronal networks was studied in vitro. We demonstrate a dose-dependent excitatory effect of MP on cultured neuronal networks, followed by a shut-down of electrical activity using the microelectrode array technique.

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Year:  2014        PMID： 25283186     DOI： 10.1007/s10571-014-0117-y

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  15 in total

Review 1.  Mechanism of action of glucocorticosteroid hormones: possible implications for therapy of neuroimmunological disorders.

Authors:  R Gold; F Buttgereit; K V Toyka
Journal:  J Neuroimmunol       Date:  2001-07-02       Impact factor: 3.478

2.  Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations.

Authors:  H Wiendl; K V Toyka; P Rieckmann; R Gold; H-P Hartung; R Hohlfeld
Journal:  J Neurol       Date:  2008-10-29       Impact factor: 4.849

3.  Effects of methylprednisolone on the GABA- and glutamate-induced currents: relevance to glucocorticoid-induced neurotoxicity and brain aging.

Authors:  A Foroutan; M M Behbehan; D K Anderson
Journal:  Steroids       Date:  1996-06       Impact factor: 2.668

4.  Quantification of acute neurotoxic effects of trimethyltin using neuronal networks cultured on microelectrode arrays.

Authors:  A Gramowski; D Schiffmann; G W Gross
Journal:  Neurotoxicology       Date:  2000-06       Impact factor: 4.294

5.  Repeat intrathecal triamcinolone acetonide application is beneficial in progressive MS patients.

Authors:  V Hoffmann; W Kuhn; S Schimrigk; S Islamova; K Hellwig; C Lukas; N Brune; D Pöhlau; H Przuntek; T Müller
Journal:  Eur J Neurol       Date:  2006-01       Impact factor: 6.089

6.  Primary culture of identified neurons from the visual cortex of postnatal rats.

Authors:  J E Huettner; R W Baughman
Journal:  J Neurosci       Date:  1986-10       Impact factor: 6.167

7.  Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat.

Authors:  U K Zettl; R Gold; K V Toyka; H P Hartung
Journal:  J Neuropathol Exp Neurol       Date:  1995-07       Impact factor: 3.685

8.  Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.

Authors:  R Gold; M Schmied; G Giegerich; H Breitschopf; H P Hartung; K V Toyka; H Lassmann
Journal:  Lab Invest       Date:  1994-08       Impact factor: 5.662

9.  Repeated intrathecal triamcinolone acetonide administration in progressive multiple sclerosis: a review.

Authors:  Mazen Abu-Mugheisib; Reiner Benecke; Uwe K Zettl
Journal:  Mult Scler Int       Date:  2011-06-26

10.  Efficacy of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients with spinal symptoms.

Authors:  Kerstin Hellwig; Franz Josef Stein; Horst Przuntek; Thomas Müller
Journal:  BMC Neurol       Date:  2004-11-07       Impact factor: 2.474
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  2 in total

1.  Long-Term Effects of Repeated Cycles of Intrathecal Triamcinolone Acetonide on Spasticity in MS Patients.

Authors:  Paulus Stefan Rommer; Frank Kamin; Mazen Abu-Mugheisib; Wolfgang Koehler; Frank Hoffmann; Alexander Winkelmann; Reiner Benecke; Uwe Klaus Zettl
Journal:  CNS Neurosci Ther       Date:  2015-11-20       Impact factor: 5.243

2.  Desensitization of the Cough Reflex Induced by Corticosteroids in Ovalbumin-Sensitized Rabbits During Artificial Limb Exercise.

Authors:  Simon Valentin; Bruno Chenuel; Silvia Demoulin-Alexikova; Bruno Demoulin; Delphine Gérard; Laurent Foucaud; Mathias Poussel
Journal:  Front Physiol       Date:  2020-05-13       Impact factor: 4.566
  2 in total

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