Sophie Bayard1, Yves Dauvilliers2, Huan Yu3, Muriel Croisier-Langenier4, Alexia Rossignol5, Mahmoud Charif5, Christian Geny5, Bertrand Carlander5, Valérie Cochen De Cock6. 1. Centre d'Investigation clinique, Centre Hospitalier Universitaire Montpellier, France; EuroMov, Laboratoire Movement to Health - M2H, Université Montpellier 1, France. Electronic address: bayardsophie@yahoo.fr. 2. Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac, Montpellier, France; Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France; Inserm, U1061, Montpellier, France. 3. Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China. 4. Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac, Montpellier, France; Laboratoire Epsylon, EA 4556, Universités Montpellier, Montpellier, France. 5. Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France. 6. EuroMov, Laboratoire Movement to Health - M2H, Université Montpellier 1, France; Pôle Sommeil et Neurologie, Clinique Beau Soleil, Montpellier, France.
Abstract
INTRODUCTION: The relationship between ICD and RBD is still not yet understood and the results from the current literature are contradictory in PD. We aimed to explore the association between rapid eye movement (REM) sleep behavior disorder (RBD) and impulse control disorder in Parkinson's disease. METHODS: Ninety-eight non-demented patients with Parkinson's disease underwent one night of video-polysomnography recording. The diagnosis of RBD was established according to clinical and polysomnographic criteria. Impulse control disorders were determined by a gold standard, semi-structured diagnostic interview. RESULTS: Half of the patients (n = 49) reported clinical history of RBD while polysomnographic diagnosis of RBD was confirmed in 31.6% of the patients (n = 31). At least one impulse control disorder was identified in 21.4% of patients, 22.6% with RBD and 20.9% without. Logistic regression controlling for potential confounders indicated that both clinical RBD (OR = 0.34, 95% CI = 0.07-1.48, P = 0.15) and polysomnographic confirmed RBD diagnoses (OR = 0.1.28, 95% CI = 0.31-5.33, P = 0.34) were not associated with impulse control disorder. CONCLUSION: In Parkinson's disease, REM Sleep Behavior Disorder is not associated with impulse control disorder. The results of our study do not support the notion that PSG-confirmed RBD and ICD share a common pathophysiology.
INTRODUCTION: The relationship between ICD and RBD is still not yet understood and the results from the current literature are contradictory in PD. We aimed to explore the association between rapid eye movement (REM) sleep behavior disorder (RBD) and impulse control disorder in Parkinson's disease. METHODS: Ninety-eight non-demented patients with Parkinson's disease underwent one night of video-polysomnography recording. The diagnosis of RBD was established according to clinical and polysomnographic criteria. Impulse control disorders were determined by a gold standard, semi-structured diagnostic interview. RESULTS: Half of the patients (n = 49) reported clinical history of RBD while polysomnographic diagnosis of RBD was confirmed in 31.6% of the patients (n = 31). At least one impulse control disorder was identified in 21.4% of patients, 22.6% with RBD and 20.9% without. Logistic regression controlling for potential confounders indicated that both clinical RBD (OR = 0.34, 95% CI = 0.07-1.48, P = 0.15) and polysomnographic confirmed RBD diagnoses (OR = 0.1.28, 95% CI = 0.31-5.33, P = 0.34) were not associated with impulse control disorder. CONCLUSION: In Parkinson's disease, REM Sleep Behavior Disorder is not associated with impulse control disorder. The results of our study do not support the notion that PSG-confirmed RBD and ICD share a common pathophysiology.
Authors: Robert S Eisinger; Adolfo Ramirez-Zamora; Samuel Carbunaru; Brandon Ptak; Zhongxing Peng-Chen; Michael S Okun; Aysegul Gunduz Journal: Front Neurol Date: 2019-02-26 Impact factor: 4.003
Authors: Fahd Baig; Mark J Kelly; Michael A Lawton; Claudio Ruffmann; Michal Rolinski; Johannes C Klein; Thomas Barber; Christine Lo; Yoav Ben-Shlomo; David Okai; Michele T Hu Journal: Neurology Date: 2019-07-16 Impact factor: 9.910
Authors: Samuel Carbunaru; Robert S Eisinger; Adolfo Ramirez-Zamora; Dana Bassan; Amin Cervantes-Arriaga; Mayela Rodriguez-Violante; Daniel Martinez-Ramirez Journal: Brain Behav Date: 2018-02-10 Impact factor: 2.708