| Literature DB >> 25281660 |
Kevin Litchfield1, Razvan Sultana1, Anthony Renwick1, Darshna Dudakia1, Sheila Seal1, Emma Ramsay1, Silvana Powell1, Anna Elliott1, Margaret Warren-Perry1, Rosalind Eeles2, Julian Peto3, Zsofia Kote-Jarai1, Kenneth Muir4, Jeremie Nsengimana5, Michael R Stratton6, Douglas F Easton7, D Timothy Bishop5, Robert A Huddart8, Nazneen Rahman2, Clare Turnbull9.
Abstract
Recent genome-wide association studies (GWAS) and subsequent meta-analyses have identified over 25 SNPs at 18 loci, together accounting for >15% of the genetic susceptibility to testicular germ cell tumour (TGCT). To identify further common SNPs associated with TGCT, here we report a three-stage experiment, involving 4098 cases and 18 972 controls. Stage 1 comprised previously published GWAS analysis of 307 291 SNPs in 986 cases and 4946 controls. In Stage 2, we used previously published customised Illumina iSelect genotyping array (iCOGs) data across 694 SNPs in 1064 cases and 10 082 controls. Here, we report new genotyping of eight SNPs showing some evidence of association in combined analysis of Stage 1 and Stage 2 in an additional 2048 cases of TGCT and 3944 controls (Stage 3). Through fixed-effects meta-analysis across three stages, we identified a novel locus at 3q25.31 (rs1510272) demonstrating association with TGCT [per-allele odds ratio (OR) = 1.16, 95% confidence interval (CI) = 1.06-1.27; P = 1.2 × 10(-9)].Entities:
Mesh：
Year: 2014 PMID： 25281660 PMCID： PMC4375409 DOI： 10.1093/hmg/ddu511
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150