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Literature DB >> 25280215

Inflamm-aging: STAT3 signaling pushes muscle stem cells off balance.

Abstract

Two recent studies shed light on mechanisms underlying muscle dysfunction in age and disease. They reveal that JAK-STAT signaling regulates myogenic differentiation, leading to a reduced reservoir of muscle stem cells. Both genetic and pharmacologic inhibition of STAT3 signaling improve stem cell homeostasis and physiology of aged and dystrophic muscles.

Entities: Disease Gene

Mesh：

Year: 2014 PMID： 25280215 DOI： 10.1016/j.stem.2014.09.010

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

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Cited

13 in total

1. Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults.

Authors: Dominique Piber; Richard Olmstead; Joshua Hyong-Jin Cho; Tuff Witarama; Christian Perez; Nicholas Dietz; Teresa E Seeman; Elizabeth C Breen; Steve W Cole; Michael R Irwin
Journal: J Gerontol A Biol Sci Med Sci Date: 2019-10-04 Impact factor: 6.053

2. Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells.

Authors: Yu Shi; Wenchao Zhou; Lin Cheng; Cong Chen; Zhi Huang; Xiaoguang Fang; Qiulian Wu; Zhicheng He; Senlin Xu; Justin D Lathia; Yifang Ping; Jeremy N Rich; Xiu-Wu Bian; Shideng Bao
Journal: Cell Death Differ Date: 2016-10-14 Impact factor: 15.828

3. Changes of Gene Expression Patterns of Muscle Pathophysiology-Related Transcription Factors During Denervated Muscle Atrophy.

Authors: Xiaoming Yang; Ming Li; Yanan Ji; Yinghao Lin; Lai Xu; Xiaosong Gu; Hualin Sun; Wei Wang; Yuntian Shen; Hua Liu; Jianwei Zhu
Journal: Front Physiol Date: 2022-06-24 Impact factor: 4.755

4. Dapagliflozin protects against doxorubicin-induced cardiotoxicity by restoring STAT3.

Authors: Wei-Ting Chang; Jhih-Yuan Shih; Wei-Chih Kan; Tsung-Hsien Lin; Yu-Wen Lin; Zhih-Cherng Chen; Chon-Seng Hong
Journal: Arch Toxicol Date: 2022-04-19 Impact factor: 6.168

5. Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity.

Authors: Donato A Rivas; Devin J McDonald; Nicholas P Rice; Prashanth H Haran; Gregory G Dolnikowski; Roger A Fielding
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2016-01-13 Impact factor: 3.619

6. The clearance of cell remnants and the regeneration of the injured muscle depend on soluble pattern recognition receptor PTX3.

Authors: Michela Vezzoli; Clara Sciorati; Lara Campana; Antonella Monno; Maria Giulia Doglio; Elena Rigamonti; Gianfranca Corna; Thierry Touvier; Alessandra Castiglioni; Annalisa Capobianco; Alberto Mantovani; Angelo A Manfredi; Cecilia Garlanda; Patrizia Rovere-Querini
Journal: Mol Med Date: 2016-11-23 Impact factor: 6.354

7. Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury.

Authors: Kristy Swiderski; Marissa K Caldow; Timur Naim; Jennifer Trieu; Annabel Chee; René Koopman; Gordon S Lynch
Journal: PLoS One Date: 2019-02-27 Impact factor: 3.240