Literature DB >> 25279575

E pluribus unum? The main protein kinase A catalytic subunit (PRKACA), a likely oncogene, and cortisol-producing tumors.

Constantine A Stratakis1.   

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Year:  2014        PMID： 25279575      PMCID： PMC4184082          DOI： 10.1210/jc.2014-3295

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


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  52 in total

1.  Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity.

Authors:  Colleen M Niswender; R Wesley Ishihara; Luke M Judge; Chao Zhang; Kevan M Shokat; G Stanley McKnight
Journal:  J Biol Chem       Date:  2002-05-28       Impact factor: 5.157

2.  Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity.

Authors:  S A Orellana; G S McKnight
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

3.  Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.

Authors:  L S Kirschner; J A Carney; S D Pack; S E Taymans; C Giatzakis; Y S Cho; Y S Cho-Chung; C A Stratakis
Journal:  Nat Genet       Date:  2000-09       Impact factor: 38.330

4.  Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex.

Authors:  L S Kirschner; F Sandrini; J Monbo; J P Lin; J A Carney; C A Stratakis
Journal:  Hum Mol Genet       Date:  2000-12-12       Impact factor: 6.150

5.  Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: role in catalysis, P-site specificity, and interaction with inhibitors.

Authors:  R T Aimes; W Hemmer; S S Taylor
Journal:  Biochemistry       Date:  2000-07-18       Impact factor: 3.162

6.  Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction.

Authors:  Bjørn S Skålhegg; Yongzhao Huang; Thomas Su; Rejean L Idzerda; G Stanley McKnight; Kimberly A Burton
Journal:  Mol Endocrinol       Date:  2002-03

7.  Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.

Authors:  Jerome Bertherat; Lionel Groussin; Fabiano Sandrini; Ludmila Matyakhina; Thalia Bei; Sotirios Stergiopoulos; Theocharis Papageorgiou; Isabelle Bourdeau; Lawrence S Kirschner; Caroline Vincent-Dejean; Karine Perlemoine; Christine Gicquel; Xavier Bertagna; Constantine A Stratakis
Journal:  Cancer Res       Date:  2003-09-01       Impact factor: 12.701

8.  Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.

Authors:  Guido Di Dalmazi; Caroline Kisker; Davide Calebiro; Massimo Mannelli; Letizia Canu; Giorgio Arnaldi; Marcus Quinkler; Nada Rayes; Antoine Tabarin; Marie Laure Jullié; Franco Mantero; Beatrice Rubin; Jens Waldmann; Detlef K Bartsch; Renato Pasquali; Martin Lohse; Bruno Allolio; Martin Fassnacht; Felix Beuschlein; Martin Reincke
Journal:  J Clin Endocrinol Metab       Date:  2014-07-24       Impact factor: 5.958

9.  Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice.

Authors:  Mark Veugelers; David Wilkes; Kimberly Burton; Deborah A McDermott; Yan Song; Marsha M Goldstein; Krista La Perle; Carl J Vaughan; Art O'Hagan; Kenneth R Bennett; Beat J Meyer; Eric Legius; Mervi Karttunen; Reijo Norio; Helena Kaariainen; Michael Lavyne; Jean-Philippe Neau; Gert Richter; Kaan Kirali; Alan Farnsworth; Karen Stapleton; Peter Morelli; Yoshinori Takanashi; John-Steven Bamforth; Franz Eitelberger; Irene Noszian; Waldimiro Manfroi; James Powers; Yoshihiko Mochizuki; Tsuneo Imai; Gary T C Ko; Deborah A Driscoll; Elizabeth Goldmuntz; Jay M Edelberg; Amanda Collins; Diana Eccles; Alan D Irvine; G Stanley McKnight; Craig T Basson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-15       Impact factor: 11.205

10.  Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors.

Authors:  Hui-Pin Hsiao; Lawrence S Kirschner; Isabelle Bourdeau; Margaret F Keil; Sosipatros A Boikos; Somya Verma; Audrey J Robinson-White; Maria Nesterova; André Lacroix; Constantine A Stratakis
Journal:  J Clin Endocrinol Metab       Date:  2009-06-09       Impact factor: 5.958
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  15 in total

Review 1.  Protein kinase A defects and cortisol-producing adrenal tumors.

Authors:  Mihail Zilbermint; Constantine A Stratakis
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2015-06       Impact factor: 3.243

2.  Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.

Authors:  Francesco Fallo; Isabella Castellano; Celso E Gomez-Sanchez; Yara Rhayem; Catia Pilon; Valentina Vicennati; Donatella Santini; Valeria Maffeis; Ambrogio Fassina; Paolo Mulatero; Felix Beuschlein; Martin Reincke
Journal:  Endocrine       Date:  2017-04-12       Impact factor: 3.633

Review 3.  Phosphodiesterase 8B and cyclic AMP signaling in the adrenal cortex.

Authors:  Leticia Ferro Leal; Eva Szarek; Fabio Faucz; Constantine A Stratakis
Journal:  Endocrine       Date:  2015-05-14       Impact factor: 3.633

Review 4.  Diagnosis and Clinical Genetics of Cushing Syndrome in Pediatrics.

Authors:  Constantine A Stratakis
Journal:  Endocrinol Metab Clin North Am       Date:  2016-06       Impact factor: 4.741

5.  Lipofuscin Accumulation in Cortisol-Producing Adenomas With and Without PRKACA Mutations.

Authors:  Anna Angelousi; Eva Szarek; Vincent Shram; Electron Kebebew; Martha Quezado; Constantine A Stratakis
Journal:  Horm Metab Res       Date:  2017-08-23       Impact factor: 2.936

6.  Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations.

Authors:  Maya B Lodish; Bo Yuan; Isaac Levy; Glenn D Braunstein; Charalampos Lyssikatos; Paraskevi Salpea; Eva Szarek; Alexander S Karageorgiadis; Elena Belyavskaya; Margarita Raygada; Fabio Rueda Faucz; Louise Izzat; Caroline Brain; James Gardner; Martha Quezado; J Aidan Carney; James R Lupski; Constantine A Stratakis
Journal:  Eur J Endocrinol       Date:  2015-06       Impact factor: 6.664

Review 7.  5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer.

Authors:  Lawrence S Kirschner; Constantine A Stratakis
Journal:  Horm Cancer       Date:  2015-12-18       Impact factor: 3.869

Review 8.  Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology.

Authors:  Rigney E Turnham; John D Scott
Journal:  Gene       Date:  2015-12-12       Impact factor: 3.688

Review 9.  Hyperplasia in glands with hormone excess.

Authors:  Stephen J Marx
Journal:  Endocr Relat Cancer       Date:  2015-09-25       Impact factor: 5.678

10.  Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.

Authors:  Sisi Liu; Emmanouil Saloustros; Edward L Mertz; Kitman Tsang; Matthew F Starost; Paraskevi Salpea; Fabio R Faucz; Eva Szarek; Maria Nesterova; Sergey Leikin; Constantine A Stratakis
Journal:  Hum Mol Genet       Date:  2015-08-05       Impact factor: 6.150
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