BACKGROUND/ METHODS: To find out the prevalence of aquaporin-antibody (Aqp-Ab) and characterize Aqp-Ab associated clinical features in NMO, Aqp-1 and Aqp-4-Abs were examined using radioimmunoprecipitation and cell-based assays, respectively. RESULTS: Aqp-4 and Aqp-1-Abs were detected in 20/30 and 8/30 NMO patients, respectively. One patient was Aqp-1-Ab single-positive, 13 patients were Aqp-4-Ab single-positive, 7 patients were Aqp-4/Aqp-1-Ab double-positive and 9 patients were seronegative. All double-positive patients had optic neuritis during the first attack. Only 2/29 MS patients and none of the control idiopathic intracranial hypertension patients were Aqp-1-Ab positive. CONCLUSION: Aqp-1-Ab is usually detected in Aqp-4-Ab positive NMO patients and might be involved in optic neuritis pathogenesis.
BACKGROUND/ METHODS: To find out the prevalence of aquaporin-antibody (Aqp-Ab) and characterize Aqp-Ab associated clinical features in NMO, Aqp-1 and Aqp-4-Abs were examined using radioimmunoprecipitation and cell-based assays, respectively. RESULTS:Aqp-4 and Aqp-1-Abs were detected in 20/30 and 8/30 NMO patients, respectively. One patient was Aqp-1-Ab single-positive, 13 patients were Aqp-4-Ab single-positive, 7 patients were Aqp-4/Aqp-1-Ab double-positive and 9 patients were seronegative. All double-positive patients had optic neuritis during the first attack. Only 2/29 MS patients and none of the control idiopathic intracranial hypertensionpatients were Aqp-1-Ab positive. CONCLUSION:Aqp-1-Ab is usually detected in Aqp-4-Ab positive NMO patients and might be involved in optic neuritis pathogenesis.
Authors: Ismael Sánchez Gomar; María Díaz Sánchez; Antonio José Uclés Sánchez; José Luis Casado Chocán; Nela Suárez-Luna; Reposo Ramírez-Lorca; Javier Villadiego; Juan José Toledo-Aral; Miriam Echevarría Journal: Int J Mol Sci Date: 2016-07-23 Impact factor: 5.923
Authors: Michal K Oklinski; Mariusz T Skowronski; Agnieszka Skowronska; Michael Rützler; Kirsten Nørgaard; John D Nieland; Tae-Hwan Kwon; Søren Nielsen Journal: Int J Mol Sci Date: 2016-12-07 Impact factor: 5.923
Authors: Lidia Stork; David Ellenberger; Klemens Ruprecht; Markus Reindl; Tim Beißbarth; Tim Friede; Tania Kümpfel; Lisa A Gerdes; Mareike Gloth; Thomas Liman; Friedemann Paul; Wolfgang Brück; Imke Metz Journal: Acta Neuropathol Date: 2020-01-16 Impact factor: 17.088
Authors: Pablo García-Miranda; Francisco J Morón-Civanto; Maria Del Mar Martínez-Olivo; Nela Suárez-Luna; Reposo Ramírez-Lorca; Lucía Lebrato-Hernández; Raquel Lamas-Pérez; Guillermo Navarro; Javier Abril-Jaramillo; Maria Isabel García-Sánchez; José Luis Casado-Chocán; Antonio José Uclés-Sánchez; Mercedes Romera; Miriam Echevarría; María Díaz-Sánchez Journal: Int J Mol Sci Date: 2019-11-19 Impact factor: 5.923