Valérie Condret-Santi1, Gladys Barragan-Jason1, Luc Valton2, Marie Denuelle3, Jonathan Curot2, Jean-Luc Nespoulous4, Emmanuel J Barbeau5. 1. Centre de Recherche Cerveau et Cognition, CNRS et Université de Toulouse, UMR 5549, 31052 Toulouse Cedex, France. 2. Centre de Recherche Cerveau et Cognition, CNRS et Université de Toulouse, UMR 5549, 31052 Toulouse Cedex, France; Explorations Neurophysiologiques, Hôpital Pierre Paul Riquet, Centre Hospitalier de Toulouse, 31052 Toulouse Cedex, France. 3. Explorations Neurophysiologiques, Hôpital Pierre Paul Riquet, Centre Hospitalier de Toulouse, 31052 Toulouse Cedex, France. 4. Octogone, Université de Toulouse, EA 4156, 31052 Toulouse Cedex, France. 5. Centre de Recherche Cerveau et Cognition, CNRS et Université de Toulouse, UMR 5549, 31052 Toulouse Cedex, France. Electronic address: emmanuel.barbeau@cerco.ups-tlse.fr.
Abstract
PURPOSE: Retrieving a specific name is sometimes difficult and can be even harder when pathology affects the temporal lobes. Word finding difficulties have been well documented in temporal lobe epilepsy (TLE) but analyses have mostly concentrated on the study of accuracy. Our aim here was to go beyond simple accuracy and to provide both a quantitative and a qualitative assessment of naming difficulties and latencies in patients with TLE. METHODS: Thirty-two patients with temporal lobe epilepsy (16 with epilepsy affecting the cerebral hemisphere dominant for language (D-TLE) and 16 with epilepsy affecting the cerebral hemisphere non-dominant for language (ND-TLE)) and 34 healthy matched control subjects were included in the study. The experiment involved naming 70 photographs of objects and 70 photographs of celebrities as fast as possible. Accuracy and naming reaction times were recorded. Following each trial, a questionnaire was used to determine the specific nature of each subject's difficulty in retrieving the name (e.g., no difficulty, paraphasia, tip of the tongue, feeling of knowing the name, etc). Reaction times were analysed both across subjects and across trials. KEY FINDINGS: D-TLE patients showed consistent and quasi-systematic impairment compared to matched control subjects on both object and famous people naming. This impairment was characterized not only by lower accuracy but also by more qualitative errors and tip of the tongue phenomena. Furthermore, minimum reaction times were slowed down by about 70 ms for objects and 150 ms for famous people naming. In contrast, patients with ND-TLE were less impaired, and their impairment was limited to object naming. SIGNIFICANCE: These results suggest that patients with TLE, in particular D-TLE, show a general impairment of lexical access. Furthermore, there was evidence of subtle difficulties (increased reaction times) in patients with TLE.
PURPOSE: Retrieving a specific name is sometimes difficult and can be even harder when pathology affects the temporal lobes. Word finding difficulties have been well documented in temporal lobe epilepsy (TLE) but analyses have mostly concentrated on the study of accuracy. Our aim here was to go beyond simple accuracy and to provide both a quantitative and a qualitative assessment of naming difficulties and latencies in patients with TLE. METHODS: Thirty-two patients with temporal lobe epilepsy (16 with epilepsy affecting the cerebral hemisphere dominant for language (D-TLE) and 16 with epilepsy affecting the cerebral hemisphere non-dominant for language (ND-TLE)) and 34 healthy matched control subjects were included in the study. The experiment involved naming 70 photographs of objects and 70 photographs of celebrities as fast as possible. Accuracy and naming reaction times were recorded. Following each trial, a questionnaire was used to determine the specific nature of each subject's difficulty in retrieving the name (e.g., no difficulty, paraphasia, tip of the tongue, feeling of knowing the name, etc). Reaction times were analysed both across subjects and across trials. KEY FINDINGS: D-TLEpatients showed consistent and quasi-systematic impairment compared to matched control subjects on both object and famous people naming. This impairment was characterized not only by lower accuracy but also by more qualitative errors and tip of the tongue phenomena. Furthermore, minimum reaction times were slowed down by about 70 ms for objects and 150 ms for famous people naming. In contrast, patients with ND-TLE were less impaired, and their impairment was limited to object naming. SIGNIFICANCE: These results suggest that patients with TLE, in particular D-TLE, show a general impairment of lexical access. Furthermore, there was evidence of subtle difficulties (increased reaction times) in patients with TLE.